Результаты исследований: Вклад в журнал › Статья › Рецензирование
Результаты исследований: Вклад в журнал › Статья › Рецензирование
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TY - JOUR
T1 - Synthesis and cytotoxic activity of (2-arylquinazolin-4-yl)hydrazones of 2-hydroxybenzaldehydes
AU - Nosova, Emiliya v.
AU - Butorin, Ilya i.
AU - Likhacheva, Margarita d.
AU - Kotovskaya, Svetlana k.
N1 - This work was supported by the Ministry of Science and Higher Education of the Russian Federation, State Contract no FEUZ-2023-0021 (N687.42B.325/23).
PY - 2023
Y1 - 2023
N2 - 2-Phenyl-6,7-difluoro and 2-(4-fluorophenyl)quinazoline derivatives bearing salicylidenhydrazino fragments at position 4 were prepared based on 4,5-difluoroantranilic acid or anthranilamide. Molecular docking to casein kinase 2 was performed; compounds with high in silico activity to CK2 were revealed. Cytotoxic activity of the synthesized compounds was studied on cancer cell line MDA-MB-231 and normal cell line WI26 VA4.
AB - 2-Phenyl-6,7-difluoro and 2-(4-fluorophenyl)quinazoline derivatives bearing salicylidenhydrazino fragments at position 4 were prepared based on 4,5-difluoroantranilic acid or anthranilamide. Molecular docking to casein kinase 2 was performed; compounds with high in silico activity to CK2 were revealed. Cytotoxic activity of the synthesized compounds was studied on cancer cell line MDA-MB-231 and normal cell line WI26 VA4.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85162133089
UR - https://elibrary.ru/item.asp?id=54268153
U2 - 10.15826/chimtech.2023.10.2.11
DO - 10.15826/chimtech.2023.10.2.11
M3 - Article
VL - 10
JO - Chimica Techno Acta
JF - Chimica Techno Acta
SN - 2409-5613
IS - 2
M1 - 202310211
ER -
ID: 41588035