Результаты исследований: Вклад в журнал › Статья › Рецензирование
Результаты исследований: Вклад в журнал › Статья › Рецензирование
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TY - JOUR
T1 - Impact of a 1,3,4-Thiadiazine Compound on Oxidative Stress Intensity in Experimental Type 2 Diabetes Mellitus
AU - Emelianov, V. v.
AU - Gette, I. f.
AU - Danilova, I. g.
AU - Sidorova, L. p.
AU - Tseiler, T. A.
AU - Mukhlynina, E. a.
N1 - The work used equipment at the CCU, IIP, UrB, RAS.
PY - 2023/6/1
Y1 - 2023/6/1
N2 - The effect of the synthetic compound 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrochloride (L17) on rats with a streptozotocin-nicotinamide model of type 2 diabetes mellitus (DM2) was studied. The experiment was performed on 50 male Wistar rats. L17 was administered intramuscularly to diabetic rats at a dose of 40 mg/kg. Modeling DM2 revealed hyperglycemia, accumulation of glycated hemoglobin (HbA1c) and malondialdehyde (MDA); a decreased content of thiols; and compensatory activation of antioxidant defense (AOD) enzymes [superoxide dismutase (SOD), catalase, glutathione peroxidase] in erythrocytes. Administration of L17 to diabetic rats was accompanied by a decrease in hyperglycemia, normalization of HbA1c and MDA levels and AOD enzyme activity, and prevention of thiol depletion. Correction of hyperglycemia and imbalance in the free-radical oxidation(AOD system in the experiment made further study of the mechanism of the antidiabetic action of L17 promising.
AB - The effect of the synthetic compound 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrochloride (L17) on rats with a streptozotocin-nicotinamide model of type 2 diabetes mellitus (DM2) was studied. The experiment was performed on 50 male Wistar rats. L17 was administered intramuscularly to diabetic rats at a dose of 40 mg/kg. Modeling DM2 revealed hyperglycemia, accumulation of glycated hemoglobin (HbA1c) and malondialdehyde (MDA); a decreased content of thiols; and compensatory activation of antioxidant defense (AOD) enzymes [superoxide dismutase (SOD), catalase, glutathione peroxidase] in erythrocytes. Administration of L17 to diabetic rats was accompanied by a decrease in hyperglycemia, normalization of HbA1c and MDA levels and AOD enzyme activity, and prevention of thiol depletion. Correction of hyperglycemia and imbalance in the free-radical oxidation(AOD system in the experiment made further study of the mechanism of the antidiabetic action of L17 promising.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85162029560
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001009376800002
U2 - 10.1007/s11094-023-02889-y
DO - 10.1007/s11094-023-02889-y
M3 - Article
VL - 57
SP - 353
EP - 357
JO - Pharmaceutical Chemistry Journal
JF - Pharmaceutical Chemistry Journal
SN - 0091-150X
IS - 3
ER -
ID: 41539204