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Impact of a 1,3,4-Thiadiazine Compound on Oxidative Stress Intensity in Experimental Type 2 Diabetes Mellitus. / Emelianov, V. v.; Gette, I. f.; Danilova, I. g. et al.
In: Pharmaceutical Chemistry Journal, Vol. 57, No. 3, 01.06.2023, p. 353-357.

Research output: Contribution to journal › Article › peer-review

Harvard

Emelianov, VV, Gette, IF, Danilova, IG, Sidorova, LP, Tseiler, TA & Mukhlynina, EA 2023, 'Impact of a 1,3,4-Thiadiazine Compound on Oxidative Stress Intensity in Experimental Type 2 Diabetes Mellitus', Pharmaceutical Chemistry Journal, vol. 57, no. 3, pp. 353-357. https://doi.org/10.1007/s11094-023-02889-y

APA

Emelianov, V. V., Gette, I. F., Danilova, I. G., Sidorova, L. P., Tseiler, T. A., & Mukhlynina, E. A. (2023). Impact of a 1,3,4-Thiadiazine Compound on Oxidative Stress Intensity in Experimental Type 2 Diabetes Mellitus. Pharmaceutical Chemistry Journal, 57(3), 353-357. https://doi.org/10.1007/s11094-023-02889-y

Vancouver

Emelianov VV, Gette IF, Danilova IG, Sidorova LP, Tseiler TA, Mukhlynina EA. Impact of a 1,3,4-Thiadiazine Compound on Oxidative Stress Intensity in Experimental Type 2 Diabetes Mellitus. Pharmaceutical Chemistry Journal. 2023 Jun 1;57(3):353-357. doi: 10.1007/s11094-023-02889-y

Author

Emelianov, V. v. ; Gette, I. f. ; Danilova, I. g. et al. / Impact of a 1,3,4-Thiadiazine Compound on Oxidative Stress Intensity in Experimental Type 2 Diabetes Mellitus. In: Pharmaceutical Chemistry Journal. 2023 ; Vol. 57, No. 3. pp. 353-357.

BibTeX

@article{82e562f4beb747f1a66b2f756114d3b7,
title = "Impact of a 1,3,4-Thiadiazine Compound on Oxidative Stress Intensity in Experimental Type 2 Diabetes Mellitus",
abstract = "The effect of the synthetic compound 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrochloride (L17) on rats with a streptozotocin-nicotinamide model of type 2 diabetes mellitus (DM2) was studied. The experiment was performed on 50 male Wistar rats. L17 was administered intramuscularly to diabetic rats at a dose of 40 mg/kg. Modeling DM2 revealed hyperglycemia, accumulation of glycated hemoglobin (HbA1c) and malondialdehyde (MDA); a decreased content of thiols; and compensatory activation of antioxidant defense (AOD) enzymes [superoxide dismutase (SOD), catalase, glutathione peroxidase] in erythrocytes. Administration of L17 to diabetic rats was accompanied by a decrease in hyperglycemia, normalization of HbA1c and MDA levels and AOD enzyme activity, and prevention of thiol depletion. Correction of hyperglycemia and imbalance in the free-radical oxidation(AOD system in the experiment made further study of the mechanism of the antidiabetic action of L17 promising.",
author = "Emelianov, {V. v.} and Gette, {I. f.} and Danilova, {I. g.} and Sidorova, {L. p.} and Tseiler, {T. A.} and Mukhlynina, {E. a.}",
note = "The work used equipment at the CCU, IIP, UrB, RAS.",
year = "2023",
month = jun,
day = "1",
doi = "10.1007/s11094-023-02889-y",
language = "English",
volume = "57",
pages = "353--357",
journal = "Pharmaceutical Chemistry Journal",
issn = "0091-150X",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Impact of a 1,3,4-Thiadiazine Compound on Oxidative Stress Intensity in Experimental Type 2 Diabetes Mellitus

AU - Emelianov, V. v.

AU - Gette, I. f.

AU - Danilova, I. g.

AU - Sidorova, L. p.

AU - Tseiler, T. A.

AU - Mukhlynina, E. a.

N1 - The work used equipment at the CCU, IIP, UrB, RAS.

PY - 2023/6/1

Y1 - 2023/6/1

N2 - The effect of the synthetic compound 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrochloride (L17) on rats with a streptozotocin-nicotinamide model of type 2 diabetes mellitus (DM2) was studied. The experiment was performed on 50 male Wistar rats. L17 was administered intramuscularly to diabetic rats at a dose of 40 mg/kg. Modeling DM2 revealed hyperglycemia, accumulation of glycated hemoglobin (HbA1c) and malondialdehyde (MDA); a decreased content of thiols; and compensatory activation of antioxidant defense (AOD) enzymes [superoxide dismutase (SOD), catalase, glutathione peroxidase] in erythrocytes. Administration of L17 to diabetic rats was accompanied by a decrease in hyperglycemia, normalization of HbA1c and MDA levels and AOD enzyme activity, and prevention of thiol depletion. Correction of hyperglycemia and imbalance in the free-radical oxidation(AOD system in the experiment made further study of the mechanism of the antidiabetic action of L17 promising.

AB - The effect of the synthetic compound 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrochloride (L17) on rats with a streptozotocin-nicotinamide model of type 2 diabetes mellitus (DM2) was studied. The experiment was performed on 50 male Wistar rats. L17 was administered intramuscularly to diabetic rats at a dose of 40 mg/kg. Modeling DM2 revealed hyperglycemia, accumulation of glycated hemoglobin (HbA1c) and malondialdehyde (MDA); a decreased content of thiols; and compensatory activation of antioxidant defense (AOD) enzymes [superoxide dismutase (SOD), catalase, glutathione peroxidase] in erythrocytes. Administration of L17 to diabetic rats was accompanied by a decrease in hyperglycemia, normalization of HbA1c and MDA levels and AOD enzyme activity, and prevention of thiol depletion. Correction of hyperglycemia and imbalance in the free-radical oxidation(AOD system in the experiment made further study of the mechanism of the antidiabetic action of L17 promising.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85162029560

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001009376800002

U2 - 10.1007/s11094-023-02889-y

DO - 10.1007/s11094-023-02889-y

M3 - Article

VL - 57

SP - 353

EP - 357

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

SN - 0091-150X

IS - 3

ER -

ID: 41539204