Результаты исследований: Вклад в журнал › Обзорная статья › Рецензирование
Результаты исследований: Вклад в журнал › Обзорная статья › Рецензирование
}
TY - JOUR
T1 - 4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application
AU - Fedin, Vladislav
AU - Obydennov, Dmitrii
AU - Usachev, Sergei
AU - Sosnovskikh, Vyacheslav
N1 - This work was financially supported by the Russian Science Foundation (grant 22-73-10236, https://rscf.ru/project/22-73-10236/(accessed on 10 December 2023)).
PY - 2023
Y1 - 2023
N2 - 4-Hydroxy-2-pyrones are of interest as potential biorenewable molecules for a sustainable transition from biomass feedstock to valuable chemical products. This review focuses on the methodologies for the synthesis of 4-hydroxy-2-pyrones published over the last 20 years. These pyrones as polyketides are widespread in Nature and possess versatile bioactivity that makes them an attractive target for synthesis and modification. Biosynthetic paths of the pyrones are actively developed and used as biotechnological approaches for the construction of natural and unnatural polysubstituted 4-hydroxy-2-pyrones. The major synthetical methods are biomimetic and are based on the cyclization of tricarbonyl compounds. Novel chemical methods of de novo synthesis based on alkyne cyclizations using transition metal complexes and ketene transformations allow for straightforward access to 4-hydroxy-2-pyrones and have been applied for the construction of natural products. Possible directions for further pyrone ring modification are discussed.
AB - 4-Hydroxy-2-pyrones are of interest as potential biorenewable molecules for a sustainable transition from biomass feedstock to valuable chemical products. This review focuses on the methodologies for the synthesis of 4-hydroxy-2-pyrones published over the last 20 years. These pyrones as polyketides are widespread in Nature and possess versatile bioactivity that makes them an attractive target for synthesis and modification. Biosynthetic paths of the pyrones are actively developed and used as biotechnological approaches for the construction of natural and unnatural polysubstituted 4-hydroxy-2-pyrones. The major synthetical methods are biomimetic and are based on the cyclization of tricarbonyl compounds. Novel chemical methods of de novo synthesis based on alkyne cyclizations using transition metal complexes and ketene transformations allow for straightforward access to 4-hydroxy-2-pyrones and have been applied for the construction of natural products. Possible directions for further pyrone ring modification are discussed.
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001130919800001
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85185691563
U2 - 10.3390/org4040037
DO - 10.3390/org4040037
M3 - Review article
VL - 4
SP - 539
EP - 561
JO - Organics
JF - Organics
SN - 2673-401X
IS - 4
ER -
ID: 51667625