Standard

4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application. / Fedin, Vladislav; Obydennov, Dmitrii; Usachev, Sergei et al.
In: Organics, Vol. 4, No. 4, 2023, p. 539-561.

Research output: Contribution to journal › Review article › peer-review

Harvard

Fedin, V, Obydennov, D, Usachev, S & Sosnovskikh, V 2023, '4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application', Organics, vol. 4, no. 4, pp. 539-561. https://doi.org/10.3390/org4040037

APA

Fedin, V., Obydennov, D., Usachev, S., & Sosnovskikh, V. (2023). 4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application. Organics, 4(4), 539-561. https://doi.org/10.3390/org4040037

Vancouver

Fedin V, Obydennov D, Usachev S, Sosnovskikh V. 4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application. Organics. 2023;4(4):539-561. doi: 10.3390/org4040037

Author

Fedin, Vladislav ; Obydennov, Dmitrii ; Usachev, Sergei et al. / 4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application. In: Organics. 2023 ; Vol. 4, No. 4. pp. 539-561.

BibTeX

@article{0135870a46204c678c538f2bb7774e19,
title = "4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application",
abstract = "4-Hydroxy-2-pyrones are of interest as potential biorenewable molecules for a sustainable transition from biomass feedstock to valuable chemical products. This review focuses on the methodologies for the synthesis of 4-hydroxy-2-pyrones published over the last 20 years. These pyrones as polyketides are widespread in Nature and possess versatile bioactivity that makes them an attractive target for synthesis and modification. Biosynthetic paths of the pyrones are actively developed and used as biotechnological approaches for the construction of natural and unnatural polysubstituted 4-hydroxy-2-pyrones. The major synthetical methods are biomimetic and are based on the cyclization of tricarbonyl compounds. Novel chemical methods of de novo synthesis based on alkyne cyclizations using transition metal complexes and ketene transformations allow for straightforward access to 4-hydroxy-2-pyrones and have been applied for the construction of natural products. Possible directions for further pyrone ring modification are discussed.",
author = "Vladislav Fedin and Dmitrii Obydennov and Sergei Usachev and Vyacheslav Sosnovskikh",
note = "This work was financially supported by the Russian Science Foundation (grant 22-73-10236, https://rscf.ru/project/22-73-10236/(accessed on 10 December 2023)).",
year = "2023",
doi = "10.3390/org4040037",
language = "English",
volume = "4",
pages = "539--561",
journal = "Organics",
issn = "2673-401X",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

RIS

TY - JOUR

T1 - 4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application

AU - Fedin, Vladislav

AU - Obydennov, Dmitrii

AU - Usachev, Sergei

AU - Sosnovskikh, Vyacheslav

N1 - This work was financially supported by the Russian Science Foundation (grant 22-73-10236, https://rscf.ru/project/22-73-10236/(accessed on 10 December 2023)).

PY - 2023

Y1 - 2023

N2 - 4-Hydroxy-2-pyrones are of interest as potential biorenewable molecules for a sustainable transition from biomass feedstock to valuable chemical products. This review focuses on the methodologies for the synthesis of 4-hydroxy-2-pyrones published over the last 20 years. These pyrones as polyketides are widespread in Nature and possess versatile bioactivity that makes them an attractive target for synthesis and modification. Biosynthetic paths of the pyrones are actively developed and used as biotechnological approaches for the construction of natural and unnatural polysubstituted 4-hydroxy-2-pyrones. The major synthetical methods are biomimetic and are based on the cyclization of tricarbonyl compounds. Novel chemical methods of de novo synthesis based on alkyne cyclizations using transition metal complexes and ketene transformations allow for straightforward access to 4-hydroxy-2-pyrones and have been applied for the construction of natural products. Possible directions for further pyrone ring modification are discussed.

AB - 4-Hydroxy-2-pyrones are of interest as potential biorenewable molecules for a sustainable transition from biomass feedstock to valuable chemical products. This review focuses on the methodologies for the synthesis of 4-hydroxy-2-pyrones published over the last 20 years. These pyrones as polyketides are widespread in Nature and possess versatile bioactivity that makes them an attractive target for synthesis and modification. Biosynthetic paths of the pyrones are actively developed and used as biotechnological approaches for the construction of natural and unnatural polysubstituted 4-hydroxy-2-pyrones. The major synthetical methods are biomimetic and are based on the cyclization of tricarbonyl compounds. Novel chemical methods of de novo synthesis based on alkyne cyclizations using transition metal complexes and ketene transformations allow for straightforward access to 4-hydroxy-2-pyrones and have been applied for the construction of natural products. Possible directions for further pyrone ring modification are discussed.

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001130919800001

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85185691563

U2 - 10.3390/org4040037

DO - 10.3390/org4040037

M3 - Review article

VL - 4

SP - 539

EP - 561

JO - Organics

JF - Organics

SN - 2673-401X

IS - 4

ER -

ID: 51667625