"The organization of information work with the population on issues of radiation safety presupposes an account of the whole variety of factors that determine the radiation situation and the medical, socio-psychological "portrait" of the population. To determine the categories of the population for the purpose of conducting mass information and explanatory work, methods of theoretical analysis of scientific literature on this issue, translation, synthesis of scientific works were used. Authors analyzed the following: regulatory legal documents; Fundamental theoretical and empirical research in the field of radiation safety, radiation ecology, hygiene, medicine, sociology, psychology; Materials of educational resource centers and public organizations. In the article, on the base of analysis of legal acts and scientific literature, authors’ approach to determination of population groups for effective information strategy on radiation safety issues is shown. Organizational and psychological aspects have been revealed. The main methods of advocacy are: lecture; Training module (educational information Internet resource, audio-lecture); Training / role playing; Visual aids / memos; Parliamentary hearings / meetings of committees, commissions, working groups, expert councils; Public hearings / proposals to the Legislation; Scientific and methodological seminars / congresses / conferences; Telecasts / broadcasts; social networks; Quizzes, game contests. Thus, based on the analysis of normative legal documents and scientific literature, the authorial attempt is made to classify groups of the population in the context of conducting mass information and explanatory work on radiation safety. It is important that the classification is carried out taking into account the organizational and psychological aspects of security."