A set of Dy3+ ions doped boro-tellurite glasses is prepared using the melt quenching method and its radiation resisting aptitude is estimated through various structural and elastic features. The results were interpreted due to the effect of TeO2 concentration in the glass systems. The observed molar volume (Vm) values reduced with the rise in the tellurium content with the creation of more bridging oxygens in the structure. The cross-link density rises the rigidity of the glass and its density. Additionally, boron-boron separation and tellurium-tellurium separation, and optical band gap were computed to prove the connectivity of the system which is noted to reduce with the rise in the tellurium content. Glass with 40% TeO2 is observed to hold high elastic moduli and consequently high density and connectivity which are vital requirements for effective radiation shielding. Moreover, the Monte Carlo N-Particle transport code version 5 is used to qualify the γ-ray shielding properties. The qualification of the shielding properties showed that the linear attenuation coefficient was enhanced by a factor of 80% from 0.248 cm−1 to 0.358 cm−1 by raising the TeO2 concentration between 0 and 40 wt %, respectively. The enhancement on linear attenuation coefficient was reflected on the half value thickness (Δ0.5, cm) and thickness equivalent (Δeq, cm) of the fabricated samples where Δ0.5 and Δeq values reduced with raising the TeO2 concentration between 0 and 40 wt %.