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Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level. / Pershina, Alexandra G.; Efimova, L. V.; Brikunova, Olga Ya. и др.
в: Nano Today, Том 56, 102300, 2024.

Результаты исследований: Вклад в журнал › Статья › Рецензирование

Harvard

Pershina, AG, Efimova, LV, Brikunova, OY, Nevskaya, KV, Sukhinina, EV, Hmelevskaya, ES, Demin, AM, Naumenko, VA, Malkeyeva, D, Kiseleva, E, Khozyainova, AA, Menyailo, ME, Denisov, EV, Volegov, AS, Uimin, MA, Krasnov, VP & Ogorodova, LM 2024, 'Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level', Nano Today, Том. 56, 102300. https://doi.org/10.1016/j.nantod.2024.102300

APA

Pershina, A. G., Efimova, L. V., Brikunova, O. Y., Nevskaya, K. V., Sukhinina, E. V., Hmelevskaya, E. S., Demin, A. M., Naumenko, V. A., Malkeyeva, D., Kiseleva, E., Khozyainova, A. A., Menyailo, M. E., Denisov, E. V., Volegov, A. S., Uimin, M. A., Krasnov, V. P., & Ogorodova, L. M. (2024). Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level. Nano Today, 56, [102300]. https://doi.org/10.1016/j.nantod.2024.102300

Vancouver

Pershina AG, Efimova LV, Brikunova OY, Nevskaya KV, Sukhinina EV, Hmelevskaya ES и др. Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level. Nano Today. 2024;56:102300. doi: 10.1016/j.nantod.2024.102300

Author

Pershina, Alexandra G. ; Efimova, L. V. ; Brikunova, Olga Ya. и др. / Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level. в: Nano Today. 2024 ; Том 56.

BibTeX

@article{3ca8c25162cc41afbdaf21e4084af93b,
title = "Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level",
abstract = "A benefit of biomedical application of nanosystems is implementation of a precise effect at the level of an individual cell, and magnetic nanoparticles (MNPs) are some of the best candidates for the development of an intelligent nanosystem with remote control. To develop a nanosystem for precise therapy, a deep understanding of the nanosystem's in vivo behavior is required. Here, we studied penetration and distribution of PEGylated iron oxide MNPs unmodified or modified with the pH low insertion peptide (a ligand for smart targeting of the tumor acidic microenvironment) in vivo in a 4T1 mouse tumor. We revealed that MNPs penetrate into the tumor via both vascular burst and endothelial transcytosis. By implementing an approach based on single-cell high-throughput RNA sequencing, we identified the populations of the cells that took up MNPs in the 4T1 tumor and revealed preferential accumulation of MNPs in regulatory Trem2+ tumor-associated macrophages. {\textcopyright} 2024",
author = "Pershina, {Alexandra G.} and Efimova, {L. V.} and Brikunova, {Olga Ya.} and Nevskaya, {Kseniya V.} and Sukhinina, {Ekaterina V.} and Hmelevskaya, {Ekaterina S.} and Demin, {Alexander M.} and Naumenko, {Victor A.} and Dina Malkeyeva and Elena Kiseleva and Khozyainova, {Anna A.} and Menyailo, {Maxim E.} and Denisov, {Evgeny V.} and Volegov, {Aleksey S.} and Uimin, {Mikhail A.} and Krasnov, {Victor P.} and Ogorodova, {Ludmila M.}",
note = "This work was supported by the Centre for Strategic Planning of the Federal Medical-Biological Agency of Russia [contract numbers No. 0373100122119000033 of 07 June 2019 and No. 0373100122120000041 of 04 June 2020].",
year = "2024",
doi = "10.1016/j.nantod.2024.102300",
language = "English",
volume = "56",
journal = "Nano Today",
issn = "1748-0132",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level

AU - Pershina, Alexandra G.

AU - Efimova, L. V.

AU - Brikunova, Olga Ya.

AU - Nevskaya, Kseniya V.

AU - Sukhinina, Ekaterina V.

AU - Hmelevskaya, Ekaterina S.

AU - Demin, Alexander M.

AU - Naumenko, Victor A.

AU - Malkeyeva, Dina

AU - Kiseleva, Elena

AU - Khozyainova, Anna A.

AU - Menyailo, Maxim E.

AU - Denisov, Evgeny V.

AU - Volegov, Aleksey S.

AU - Uimin, Mikhail A.

AU - Krasnov, Victor P.

AU - Ogorodova, Ludmila M.

N1 - This work was supported by the Centre for Strategic Planning of the Federal Medical-Biological Agency of Russia [contract numbers No. 0373100122119000033 of 07 June 2019 and No. 0373100122120000041 of 04 June 2020].

PY - 2024

Y1 - 2024

N2 - A benefit of biomedical application of nanosystems is implementation of a precise effect at the level of an individual cell, and magnetic nanoparticles (MNPs) are some of the best candidates for the development of an intelligent nanosystem with remote control. To develop a nanosystem for precise therapy, a deep understanding of the nanosystem's in vivo behavior is required. Here, we studied penetration and distribution of PEGylated iron oxide MNPs unmodified or modified with the pH low insertion peptide (a ligand for smart targeting of the tumor acidic microenvironment) in vivo in a 4T1 mouse tumor. We revealed that MNPs penetrate into the tumor via both vascular burst and endothelial transcytosis. By implementing an approach based on single-cell high-throughput RNA sequencing, we identified the populations of the cells that took up MNPs in the 4T1 tumor and revealed preferential accumulation of MNPs in regulatory Trem2+ tumor-associated macrophages. © 2024

AB - A benefit of biomedical application of nanosystems is implementation of a precise effect at the level of an individual cell, and magnetic nanoparticles (MNPs) are some of the best candidates for the development of an intelligent nanosystem with remote control. To develop a nanosystem for precise therapy, a deep understanding of the nanosystem's in vivo behavior is required. Here, we studied penetration and distribution of PEGylated iron oxide MNPs unmodified or modified with the pH low insertion peptide (a ligand for smart targeting of the tumor acidic microenvironment) in vivo in a 4T1 mouse tumor. We revealed that MNPs penetrate into the tumor via both vascular burst and endothelial transcytosis. By implementing an approach based on single-cell high-throughput RNA sequencing, we identified the populations of the cells that took up MNPs in the 4T1 tumor and revealed preferential accumulation of MNPs in regulatory Trem2+ tumor-associated macrophages. © 2024

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85193047315

U2 - 10.1016/j.nantod.2024.102300

DO - 10.1016/j.nantod.2024.102300

M3 - Article

VL - 56

JO - Nano Today

JF - Nano Today

SN - 1748-0132

M1 - 102300

ER -

ID: 57310157