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Результаты исследований: Вклад в журнал › Статья › Рецензирование
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TY - JOUR
T1 - Iron and Molybdenum Content in the Immune-Privileged Organs of Rats upon the Administration of Nanocluster Porous Spherical Keplerate-Type Polyoxometalate {Mo72Fe30}
AU - Ostroushko, A. A.
AU - Gette, I. F.
AU - Danilova, I. G.
AU - Medvedeva, S. Yu.
AU - Koveza, E. V.
AU - Andreeva, M. A.
AU - Morozova, M. V.
AU - Tonkushina, M. O.
N1 - This work was partially financially supported within the framework of a State Task from the Ministry of Science and Higher Education of the Russian Federation (project no. 123031300049-8).
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Studies of the concentration of iron and molybdenum in the immune-privileged organs of rats without a pathology and after simulating posthemorrhagic anemia, which received intramuscular injections of Keplerate-type nanocluster porous spherical polyoxometalate (POM) {Mo72Fe30}, are conducted. The blood–testis barrier is the most resistant to the penetration of the components of POM, the blood–brain and blood–ocular barriers possess a lower resistance (accumulation of iron after 30 injections of POM), and the blood–thymus barrier is the least resistant. The borrowing of iron from immune-privileged organs such as the brain, eyeballs, and thymus occurs in the early stages (1 to 7 days) of posthemorrhagic anemia. Posthemorrhagic anemia decreases the resistance of the blood–brain barrier and is accompanied by the excessive accumulation of iron after seven injections of POM.
AB - Studies of the concentration of iron and molybdenum in the immune-privileged organs of rats without a pathology and after simulating posthemorrhagic anemia, which received intramuscular injections of Keplerate-type nanocluster porous spherical polyoxometalate (POM) {Mo72Fe30}, are conducted. The blood–testis barrier is the most resistant to the penetration of the components of POM, the blood–brain and blood–ocular barriers possess a lower resistance (accumulation of iron after 30 injections of POM), and the blood–thymus barrier is the least resistant. The borrowing of iron from immune-privileged organs such as the brain, eyeballs, and thymus occurs in the early stages (1 to 7 days) of posthemorrhagic anemia. Posthemorrhagic anemia decreases the resistance of the blood–brain barrier and is accompanied by the excessive accumulation of iron after seven injections of POM.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85184838048
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001160071500001
U2 - 10.1134/S2635167623601079
DO - 10.1134/S2635167623601079
M3 - Article
VL - 18
SP - 945
EP - 951
JO - Nanobiotechnology Reports
JF - Nanobiotechnology Reports
SN - 2635-1676
IS - 6
ER -
ID: 52960242