We present the study of domain structure evolution during polarization reversal in lithium niobate crystal with an initial tailored polydomain state representing a matrix of isolated domains arranged in a square lattice. Domain kinetics during switching differs significantly from the initial single domain state. Growing domains elongate in Y crystallographic direction coinciding with the 2D lattice direction. The field dependence of main domain walls follows the activation law. Typical switching current consists of many Barkhausen pulses separated by low current regions. Korcak’s analysis of switching current has demonstrated the Hurst exponent below 0.5, which indicates an anti-persistent character of the process. © 2023 Taylor & Francis Group, LLC.