Determination of 6-Nitro-7-(4'-Nitrophenyl)-5-Ethyl-4,7-Dihydropyrazolo[1,5-a]Pyrimidine-3-Carboxylate as a Potential Antitumor Agent by Voltammetry

Standard

Determination of 6-Nitro-7-(4'-Nitrophenyl)-5-Ethyl-4,7-Dihydropyrazolo[1,5-a]Pyrimidine-3-Carboxylate as a Potential Antitumor Agent by Voltammetry. / Mozharovskaia, P. N.; Ivoilova, A. V.; Terekhova, A. A. и др.
в: Journal of Analytical Chemistry, Том 78, № 3, 01.03.2023, стр. 378-384.

Результаты исследований: Вклад в журнал › Статья › Рецензирование

BibTeX

@article{4959b2b74b8a4b2dba75cd4c2242be1a,

title = "Determination of 6-Nitro-7-(4'-Nitrophenyl)-5-Ethyl-4,7-Dihydropyrazolo[1,5-a]Pyrimidine-3-Carboxylate as a Potential Antitumor Agent by Voltammetry",

abstract = "6-Nitro-7-(4'-nitrophenyl)-5-ethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (1) is one of promising antitumor compounds exhibiting biological activity against type 2 casein kinase, which is currently considered as a promising target in chemotherapy. Using the method of cyclic voltammetry, it was shown that the electrochemical activity of compound 1 in a mixed solution of Tris-HCl and ethanol (1 : 1) at pH 7.5 on a glassy-carbon electrode is due to the electrochemical reduction of the nitro group conjugated with the phenyl ring. A method was developed for the determination of compound 1 by direct cathodic square-wave voltammetry. The linearity region of the corresponding calibration curve obtained in a solution of a mixture of Tris-HCl and ethanol (1 : 1) at pH 7.5 is 5–500 mg/L (R2 = 0.988), the limit of detection is 0.8 mg/L, the limit of quantification is 2.4 mg/L. The accuracy of the developed procedure is close to 100%, the relative standard deviation is 1.4%.",

author = "Mozharovskaia, {P. N.} and Ivoilova, {A. V.} and Terekhova, {A. A.} and Tsmokalyuk, {A. N.} and Ivanova, {A. V.} and Kozitsina, {A. N.} and Rusinov, {V. L.}",

note = "This work was supported by the Ministry of Science and Higher Education of the Russian Federation, project no. FEUZ-2020-0058 (N687.42B.223/20).",

year = "2023",

month = mar,

day = "1",

doi = "10.1134/S1061934823020089",

language = "English",

volume = "78",

pages = "378--384",

journal = "Journal of Analytical Chemistry",

issn = "1061-9348",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "3",

}

RIS

TY - JOUR

T1 - Determination of 6-Nitro-7-(4'-Nitrophenyl)-5-Ethyl-4,7-Dihydropyrazolo[1,5-a]Pyrimidine-3-Carboxylate as a Potential Antitumor Agent by Voltammetry

AU - Mozharovskaia, P. N.

AU - Ivoilova, A. V.

AU - Terekhova, A. A.

AU - Tsmokalyuk, A. N.

AU - Ivanova, A. V.

AU - Kozitsina, A. N.

AU - Rusinov, V. L.

N1 - This work was supported by the Ministry of Science and Higher Education of the Russian Federation, project no. FEUZ-2020-0058 (N687.42B.223/20).

PY - 2023/3/1

Y1 - 2023/3/1

N2 - 6-Nitro-7-(4'-nitrophenyl)-5-ethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (1) is one of promising antitumor compounds exhibiting biological activity against type 2 casein kinase, which is currently considered as a promising target in chemotherapy. Using the method of cyclic voltammetry, it was shown that the electrochemical activity of compound 1 in a mixed solution of Tris-HCl and ethanol (1 : 1) at pH 7.5 on a glassy-carbon electrode is due to the electrochemical reduction of the nitro group conjugated with the phenyl ring. A method was developed for the determination of compound 1 by direct cathodic square-wave voltammetry. The linearity region of the corresponding calibration curve obtained in a solution of a mixture of Tris-HCl and ethanol (1 : 1) at pH 7.5 is 5–500 mg/L (R2 = 0.988), the limit of detection is 0.8 mg/L, the limit of quantification is 2.4 mg/L. The accuracy of the developed procedure is close to 100%, the relative standard deviation is 1.4%.

AB - 6-Nitro-7-(4'-nitrophenyl)-5-ethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (1) is one of promising antitumor compounds exhibiting biological activity against type 2 casein kinase, which is currently considered as a promising target in chemotherapy. Using the method of cyclic voltammetry, it was shown that the electrochemical activity of compound 1 in a mixed solution of Tris-HCl and ethanol (1 : 1) at pH 7.5 on a glassy-carbon electrode is due to the electrochemical reduction of the nitro group conjugated with the phenyl ring. A method was developed for the determination of compound 1 by direct cathodic square-wave voltammetry. The linearity region of the corresponding calibration curve obtained in a solution of a mixture of Tris-HCl and ethanol (1 : 1) at pH 7.5 is 5–500 mg/L (R2 = 0.988), the limit of detection is 0.8 mg/L, the limit of quantification is 2.4 mg/L. The accuracy of the developed procedure is close to 100%, the relative standard deviation is 1.4%.

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=000983214500013

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85158893188

U2 - 10.1134/S1061934823020089

DO - 10.1134/S1061934823020089

M3 - Article

VL - 78

SP - 378

EP - 384

JO - Journal of Analytical Chemistry

JF - Journal of Analytical Chemistry

SN - 1061-9348

IS - 3

ER -

ID: 39181044