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Результаты исследований: Вклад в журнал › Статья › Рецензирование
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TY - JOUR
T1 - Association of Keplerate-Type Polyoxometalate {Mo72Fe30} with Tetracycline: Nature of Binding Sites and Antimicrobial Action
AU - Grzhegorzhevskii, Kirill
AU - Tonkushina, Margarita
AU - Gushchin, Pavel
AU - Gagarin, Ilya
AU - Ermoshin, Alexander
AU - Belova, Kseniya
AU - Prokofyeva, Anna
AU - Ostroushko, Alexander
AU - Novikov, Alexander
N1 - The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program) is gratefully acknowledged.
PY - 2023
Y1 - 2023
N2 - The association process between the tetracycline (TC) antibiotic molecule and Keplerate-type nanocluster polyoxometalate (POM) {Mo72Fe30} was studied in aqueous solution. The novel supramolecular ensemble {Mo72Fe30}@TC12.5 was produced, its composition and structure were revealed by means of elemental analysis (C, N, H) and vibrational spectroscopy (IR and Raman). Based on the spectral data, the POM structure’s integrity was confirmed and binding sites of TC with the Keplerate {Mo72Fe30} surface were found. Due to thermogravimetric analysis (TG) and in-situ Raman spectroscopy during the process of {Mo72Fe30}@TC12.5 thermal destruction, we showed a significant change in the phase composition of POM’s destruction products after association with TC. The antibacterial activity of the obtained complex {Mo72Fe30}@TC12.5 was examined. The experimental results allowed us to note the partial inhibition of TC’s antibacterial activity owing to the coordination of TC to FeIII centers, in turn, which hinders the participation of TC in coordination via Mg2+ of ribosomal subunits 30S in bacteria. © 2022 by the authors.
AB - The association process between the tetracycline (TC) antibiotic molecule and Keplerate-type nanocluster polyoxometalate (POM) {Mo72Fe30} was studied in aqueous solution. The novel supramolecular ensemble {Mo72Fe30}@TC12.5 was produced, its composition and structure were revealed by means of elemental analysis (C, N, H) and vibrational spectroscopy (IR and Raman). Based on the spectral data, the POM structure’s integrity was confirmed and binding sites of TC with the Keplerate {Mo72Fe30} surface were found. Due to thermogravimetric analysis (TG) and in-situ Raman spectroscopy during the process of {Mo72Fe30}@TC12.5 thermal destruction, we showed a significant change in the phase composition of POM’s destruction products after association with TC. The antibacterial activity of the obtained complex {Mo72Fe30}@TC12.5 was examined. The experimental results allowed us to note the partial inhibition of TC’s antibacterial activity owing to the coordination of TC to FeIII centers, in turn, which hinders the participation of TC in coordination via Mg2+ of ribosomal subunits 30S in bacteria. © 2022 by the authors.
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U2 - 10.3390/inorganics11010009
DO - 10.3390/inorganics11010009
M3 - Article
VL - 11
JO - Inorganics
JF - Inorganics
SN - 2304-6740
IS - 1
M1 - 9
ER -
ID: 33632375