Результаты исследований: Вклад в журнал › Статья › Рецензирование
Результаты исследований: Вклад в журнал › Статья › Рецензирование
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TY - JOUR
T1 - Antioxidant properties of 2,5-substituted 6H-1,3,4-thiadiazines promising for experimental therapy of diabetes mellitus
AU - Gerasimova, E. L.
AU - Gazizullina, E. G.
AU - Igdisanova, D. I.
AU - Sidorova, L. P.
AU - Tseitler, T. A.
AU - Emelianov, V. V.
AU - Chupakhin, O. N.
AU - Ivanova, A. V.
N1 - This work was financially supported by the Russian Foundation for Basic Research (Project No. 19-29-08015 mk).
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Antioxidant properties of synthetic 2,5-substituted 6H-1,3,4-thiadiazines were comprehensively studied using potentiometric methods based on the reactions of electron transfer (ET mechanism) and hydrogen atom transfer (HAT mechanism) from the anti-oxidant to oxidant molecule. The kinetic parameters of the reactions with various oxidizing agents were estimated taking into account peculiarities of the transformation of 2,5-substituted 6H-1,3,4-thiadiazines in solution. The relationships “structure—antioxidant properties” are established. The role of the electron-donating and electron-withdrawing properties of substituents in positions 2 and 5 of the 1,3,4-thiadiazine ring in the manifestation of antioxidant properties is examined.
AB - Antioxidant properties of synthetic 2,5-substituted 6H-1,3,4-thiadiazines were comprehensively studied using potentiometric methods based on the reactions of electron transfer (ET mechanism) and hydrogen atom transfer (HAT mechanism) from the anti-oxidant to oxidant molecule. The kinetic parameters of the reactions with various oxidizing agents were estimated taking into account peculiarities of the transformation of 2,5-substituted 6H-1,3,4-thiadiazines in solution. The relationships “structure—antioxidant properties” are established. The role of the electron-donating and electron-withdrawing properties of substituents in positions 2 and 5 of the 1,3,4-thiadiazine ring in the manifestation of antioxidant properties is examined.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85149073349
UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=000971659000017
U2 - 10.1007/s11172-022-3702-0
DO - 10.1007/s11172-022-3702-0
M3 - Article
VL - 71
SP - 2730
EP - 2739
JO - Russian Chemical Bulletin
JF - Russian Chemical Bulletin
SN - 1066-5285
IS - 12
ER -
ID: 35502479