Standard

Voltammetric Determination of 7-Ethylthio-3-Nitro-1,2,4-Triazolo[5,1-c]-1,2,4-Triazin-4-One Dihydrate Sodium Salt as a Potential Antiviral Drug. / Mozharovskaia, P.; Ivoilova, A.; Dem’yanovich, T. et al.
In: Journal of Analytical Chemistry, Vol. 78, No. 12, 01.12.2023, p. 1688-1693.

Research output: Contribution to journal › Article › peer-review

Harvard

Mozharovskaia, P, Ivoilova, A, Dem’yanovich, T, Balin, I, Malakhova, N, Ivanova, A, Kozitsina, A, Matern, A & Rusinov, VL 2023, 'Voltammetric Determination of 7-Ethylthio-3-Nitro-1,2,4-Triazolo[5,1-c]-1,2,4-Triazin-4-One Dihydrate Sodium Salt as a Potential Antiviral Drug', Journal of Analytical Chemistry, vol. 78, no. 12, pp. 1688-1693. https://doi.org/10.1134/S1061934823120122

APA

Mozharovskaia, P., Ivoilova, A., Dem’yanovich, T., Balin, I., Malakhova, N., Ivanova, A., Kozitsina, A., Matern, A., & Rusinov, V. L. (2023). Voltammetric Determination of 7-Ethylthio-3-Nitro-1,2,4-Triazolo[5,1-c]-1,2,4-Triazin-4-One Dihydrate Sodium Salt as a Potential Antiviral Drug. Journal of Analytical Chemistry, 78(12), 1688-1693. https://doi.org/10.1134/S1061934823120122

Vancouver

Mozharovskaia P, Ivoilova A, Dem’yanovich T, Balin I, Malakhova N, Ivanova A et al. Voltammetric Determination of 7-Ethylthio-3-Nitro-1,2,4-Triazolo[5,1-c]-1,2,4-Triazin-4-One Dihydrate Sodium Salt as a Potential Antiviral Drug. Journal of Analytical Chemistry. 2023 Dec 1;78(12):1688-1693. doi: 10.1134/S1061934823120122

Author

Mozharovskaia, P. ; Ivoilova, A. ; Dem’yanovich, T. et al. / Voltammetric Determination of 7-Ethylthio-3-Nitro-1,2,4-Triazolo[5,1-c]-1,2,4-Triazin-4-One Dihydrate Sodium Salt as a Potential Antiviral Drug. In: Journal of Analytical Chemistry. 2023 ; Vol. 78, No. 12. pp. 1688-1693.

BibTeX

@article{8ef266747ad3406e8878b798b276d385,
title = "Voltammetric Determination of 7-Ethylthio-3-Nitro-1,2,4-Triazolo[5,1-c]-1,2,4-Triazin-4-One Dihydrate Sodium Salt as a Potential Antiviral Drug",
abstract = "The sodium salt of 7-ethylthio-3-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazin-4-one dihydrate (1) is one of promising antiviral compounds that have shown a pronounced biological activity against influenza virus subtype H5N1, West Nile, and SARS (severe acute respiratory syndrome). Using cyclic voltammetry, it was shown that the electrochemical activity of compound 1 in a Britton–Robinson buffer solution (BRB) of pH 2.0 on a glassy carbon electrode is due to the electrochemical reduction of the nitro group conjugated with the heterocyclic system. A method was developed for the determination of compound 1 by direct cathodic square-wave voltammetry. The linearity region of the calibration curve in a BRB solution of pH 7.0 is 10–300 mg/L (R2 = 0.999), the limit of detection is 1.5 mg/L, and the limit of quantification is 4.5 mg/L. The accuracy of the developed procedure is close to 100%, the relative standard deviation is 3.6%.",
author = "P. Mozharovskaia and A. Ivoilova and T. Dem{\textquoteright}yanovich and I. Balin and N. Malakhova and A. Ivanova and A. Kozitsina and A. Matern and Rusinov, {V. l.}",
note = "The work was supported by the Ministry of Science and Higher Education of the Russian Federation, State Contract no. FEUZ-2023-0021 (N687.42B.325/23).",
year = "2023",
month = dec,
day = "1",
doi = "10.1134/S1061934823120122",
language = "English",
volume = "78",
pages = "1688--1693",
journal = "Journal of Analytical Chemistry",
issn = "1061-9348",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "12",

}

RIS

TY - JOUR

T1 - Voltammetric Determination of 7-Ethylthio-3-Nitro-1,2,4-Triazolo[5,1-c]-1,2,4-Triazin-4-One Dihydrate Sodium Salt as a Potential Antiviral Drug

AU - Mozharovskaia, P.

AU - Ivoilova, A.

AU - Dem’yanovich, T.

AU - Balin, I.

AU - Malakhova, N.

AU - Ivanova, A.

AU - Kozitsina, A.

AU - Matern, A.

AU - Rusinov, V. l.

N1 - The work was supported by the Ministry of Science and Higher Education of the Russian Federation, State Contract no. FEUZ-2023-0021 (N687.42B.325/23).

PY - 2023/12/1

Y1 - 2023/12/1

N2 - The sodium salt of 7-ethylthio-3-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazin-4-one dihydrate (1) is one of promising antiviral compounds that have shown a pronounced biological activity against influenza virus subtype H5N1, West Nile, and SARS (severe acute respiratory syndrome). Using cyclic voltammetry, it was shown that the electrochemical activity of compound 1 in a Britton–Robinson buffer solution (BRB) of pH 2.0 on a glassy carbon electrode is due to the electrochemical reduction of the nitro group conjugated with the heterocyclic system. A method was developed for the determination of compound 1 by direct cathodic square-wave voltammetry. The linearity region of the calibration curve in a BRB solution of pH 7.0 is 10–300 mg/L (R2 = 0.999), the limit of detection is 1.5 mg/L, and the limit of quantification is 4.5 mg/L. The accuracy of the developed procedure is close to 100%, the relative standard deviation is 3.6%.

AB - The sodium salt of 7-ethylthio-3-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazin-4-one dihydrate (1) is one of promising antiviral compounds that have shown a pronounced biological activity against influenza virus subtype H5N1, West Nile, and SARS (severe acute respiratory syndrome). Using cyclic voltammetry, it was shown that the electrochemical activity of compound 1 in a Britton–Robinson buffer solution (BRB) of pH 2.0 on a glassy carbon electrode is due to the electrochemical reduction of the nitro group conjugated with the heterocyclic system. A method was developed for the determination of compound 1 by direct cathodic square-wave voltammetry. The linearity region of the calibration curve in a BRB solution of pH 7.0 is 10–300 mg/L (R2 = 0.999), the limit of detection is 1.5 mg/L, and the limit of quantification is 4.5 mg/L. The accuracy of the developed procedure is close to 100%, the relative standard deviation is 3.6%.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85183619814

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001156728900005

U2 - 10.1134/S1061934823120122

DO - 10.1134/S1061934823120122

M3 - Article

VL - 78

SP - 1688

EP - 1693

JO - Journal of Analytical Chemistry

JF - Journal of Analytical Chemistry

SN - 1061-9348

IS - 12

ER -

ID: 52294638