A speckle interferometry setup is mounted, tested and approved that allows the analysis of intracellular processes with large optical magnification. For different part of the cell, the dependences of speckle image correlation coefficients upon time are found. It is shown that the method allows the detection of differences in the process that occur in the nutrient solution outside the cell and inside the cell, as well as those occurring in different parts of the cell. © 2016 Journal of Biomedical Photonics & Engineering.