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The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines]. / Barkovskii, Savelii V.; Ulitko, Maria V.; Barkov, Alexey Yu. et al.
In: Chemistry of Heterocyclic Compounds, Vol. 58, No. 8-9, 01.09.2022, p. 462-472.

Research output: Contribution to journal › Article › peer-review

Harvard

Barkovskii, SV, Ulitko, MV, Barkov, AY, Kochnev, IА, Zimnitskiy, NS, Korotaev, VY, Sosnovskikh, VY, Stepanyuk, RА & Madzhidov, TI 2022, 'The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines]', Chemistry of Heterocyclic Compounds, vol. 58, no. 8-9, pp. 462-472. https://doi.org/10.1007/s10593-022-03113-7

APA

Barkovskii, S. V., Ulitko, M. V., Barkov, A. Y., Kochnev, I. А., Zimnitskiy, N. S., Korotaev, V. Y., Sosnovskikh, V. Y., Stepanyuk, R. А., & Madzhidov, T. I. (2022). The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines]. Chemistry of Heterocyclic Compounds, 58(8-9), 462-472. https://doi.org/10.1007/s10593-022-03113-7

Vancouver

Barkovskii SV, Ulitko MV, Barkov AY, Kochnev IА, Zimnitskiy NS, Korotaev VY et al. The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines]. Chemistry of Heterocyclic Compounds. 2022 Sept 1;58(8-9):462-472. doi: 10.1007/s10593-022-03113-7

Author

Barkovskii, Savelii V. ; Ulitko, Maria V. ; Barkov, Alexey Yu. et al. / The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines]. In: Chemistry of Heterocyclic Compounds. 2022 ; Vol. 58, No. 8-9. pp. 462-472.

BibTeX

@article{c75e3fb8652b4a7bace476ad8e027fa1,
title = "The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines]",
abstract = "A method for a regio- and stereoselective synthesis of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines] in 52-85% yields based on the three-component reaction of 3-nitro-2-trifluoromethyl-2H-chromenes with azomethine ylides generated in situ from benzylamines and indeno[1,2-b]quinoxalin-11-one by heating under reflux in CH2Cl2 for 2 h in the presence of 0.1 equiv of pyrrolidine was developed. The resulting compounds exhibited moderate cytotoxic activity against HeLa human cervical carcinoma cells in the concentration range of 10(-5)-10(-4) M.",
author = "Barkovskii, {Savelii V.} and Ulitko, {Maria V.} and Barkov, {Alexey Yu.} and Kochnev, {Ivan А.} and Zimnitskiy, {Nikolay S.} and Korotaev, {Vladislav Yu.} and Sosnovskikh, {Vyacheslav Ya.} and Stepanyuk, {Roman А.} and Madzhidov, {Timur I.}",
note = "This work was supported financially by the Russian Foundation for Basic Research (project no. 20-03-00716) within the framework of the State assignment of the Ministry of Science and Higher Education of the Russian Federation (project FEUZ-2020-0052). The authors are grateful to the staff of the Center for Collective Use “Spectroscopy and Analysis of Organic Compounds” of the Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences for help in conducting physicochemical studies.",
year = "2022",
month = sep,
day = "1",
doi = "10.1007/s10593-022-03113-7",
language = "English",
volume = "58",
pages = "462--472",
journal = "Chemistry of Heterocyclic Compounds",
issn = "0009-3122",
publisher = "Springer Verlag",
number = "8-9",

}

RIS

TY - JOUR

T1 - The synthesis and cytotoxic activity of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines]

AU - Barkovskii, Savelii V.

AU - Ulitko, Maria V.

AU - Barkov, Alexey Yu.

AU - Kochnev, Ivan А.

AU - Zimnitskiy, Nikolay S.

AU - Korotaev, Vladislav Yu.

AU - Sosnovskikh, Vyacheslav Ya.

AU - Stepanyuk, Roman А.

AU - Madzhidov, Timur I.

N1 - This work was supported financially by the Russian Foundation for Basic Research (project no. 20-03-00716) within the framework of the State assignment of the Ministry of Science and Higher Education of the Russian Federation (project FEUZ-2020-0052). The authors are grateful to the staff of the Center for Collective Use “Spectroscopy and Analysis of Organic Compounds” of the Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences for help in conducting physicochemical studies.

PY - 2022/9/1

Y1 - 2022/9/1

N2 - A method for a regio- and stereoselective synthesis of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines] in 52-85% yields based on the three-component reaction of 3-nitro-2-trifluoromethyl-2H-chromenes with azomethine ylides generated in situ from benzylamines and indeno[1,2-b]quinoxalin-11-one by heating under reflux in CH2Cl2 for 2 h in the presence of 0.1 equiv of pyrrolidine was developed. The resulting compounds exhibited moderate cytotoxic activity against HeLa human cervical carcinoma cells in the concentration range of 10(-5)-10(-4) M.

AB - A method for a regio- and stereoselective synthesis of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,11'-indeno[1,2-b]quinoxalines] in 52-85% yields based on the three-component reaction of 3-nitro-2-trifluoromethyl-2H-chromenes with azomethine ylides generated in situ from benzylamines and indeno[1,2-b]quinoxalin-11-one by heating under reflux in CH2Cl2 for 2 h in the presence of 0.1 equiv of pyrrolidine was developed. The resulting compounds exhibited moderate cytotoxic activity against HeLa human cervical carcinoma cells in the concentration range of 10(-5)-10(-4) M.

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=000864239000006

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85143667826

U2 - 10.1007/s10593-022-03113-7

DO - 10.1007/s10593-022-03113-7

M3 - Article

VL - 58

SP - 462

EP - 472

JO - Chemistry of Heterocyclic Compounds

JF - Chemistry of Heterocyclic Compounds

SN - 0009-3122

IS - 8-9

ER -

ID: 31737962