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The emerging complexity of molecular pathways implicated in mouse self-grooming behavior. / Ikrin, Aleksey N.; Moskalenko, Anastasia M.; Mukhamadeev, Radmir R. et al.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 127, 110840, 01.12.2023.

Research output: Contribution to journal › Article › peer-review

Harvard

Ikrin, AN, Moskalenko, AM, Mukhamadeev, RR, De Abreu, M, Kolesnikova, T & Kalueff, A 2023, 'The emerging complexity of molecular pathways implicated in mouse self-grooming behavior', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 127, 110840. https://doi.org/10.1016/j.pnpbp.2023.110840

APA

Ikrin, A. N., Moskalenko, A. M., Mukhamadeev, R. R., De Abreu, M., Kolesnikova, T., & Kalueff, A. (2023). The emerging complexity of molecular pathways implicated in mouse self-grooming behavior. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 127, [110840]. https://doi.org/10.1016/j.pnpbp.2023.110840

Vancouver

Ikrin AN, Moskalenko AM, Mukhamadeev RR, De Abreu M, Kolesnikova T, Kalueff A. The emerging complexity of molecular pathways implicated in mouse self-grooming behavior. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2023 Dec 1;127:110840. doi: 10.1016/j.pnpbp.2023.110840

Author

Ikrin, Aleksey N. ; Moskalenko, Anastasia M. ; Mukhamadeev, Radmir R. et al. / The emerging complexity of molecular pathways implicated in mouse self-grooming behavior. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2023 ; Vol. 127.

BibTeX

@article{fe2a635451c141ada118d036f2d95f3a,
title = "The emerging complexity of molecular pathways implicated in mouse self-grooming behavior",
abstract = "Rodent self-grooming is an important complex behavior, and its deficits are translationally relevant to a wide range of neuropsychiatric disorders. Here, we analyzed a comprehensive dataset of 227 genes whose mutations are known to evoke aberrant self-grooming in mice. Using these genes, we constructed the network of their established protein-protein interactions (PPI), yielding several distinct molecular clusters related to postsynaptic density, the Wnt signaling, transcription factors, neuronal cell cycle, NOS neurotransmission, microtubule regulation, neuronal differentiation/trafficking, neurodevelopment and mitochondrial function. Utilizing further bioinformatics analyses, we also identified novel central ({\textquoteleft}hub{\textquoteright}) proteins within these clusters, whose genes may also be implicated in aberrant self-grooming and other repetitive behaviors in general. Untangling complex molecular pathways of this important behavior using in silico approaches contributes to our understanding of related neurological disorders, and may suggest novel potential targets for their pharmacological or gene therapy.",
author = "Ikrin, {Aleksey N.} and Moskalenko, {Anastasia M.} and Mukhamadeev, {Radmir R.} and {De Abreu}, Murilo and Tatiana Kolesnikova and Allan Kalueff",
note = "The study is supported by St. Petersburg State University (Project ID 93020614 ). The research partially used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684).",
year = "2023",
month = dec,
day = "1",
doi = "10.1016/j.pnpbp.2023.110840",
language = "English",
volume = "127",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - The emerging complexity of molecular pathways implicated in mouse self-grooming behavior

AU - Ikrin, Aleksey N.

AU - Moskalenko, Anastasia M.

AU - Mukhamadeev, Radmir R.

AU - De Abreu, Murilo

AU - Kolesnikova, Tatiana

AU - Kalueff, Allan

N1 - The study is supported by St. Petersburg State University (Project ID 93020614 ). The research partially used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684).

PY - 2023/12/1

Y1 - 2023/12/1

N2 - Rodent self-grooming is an important complex behavior, and its deficits are translationally relevant to a wide range of neuropsychiatric disorders. Here, we analyzed a comprehensive dataset of 227 genes whose mutations are known to evoke aberrant self-grooming in mice. Using these genes, we constructed the network of their established protein-protein interactions (PPI), yielding several distinct molecular clusters related to postsynaptic density, the Wnt signaling, transcription factors, neuronal cell cycle, NOS neurotransmission, microtubule regulation, neuronal differentiation/trafficking, neurodevelopment and mitochondrial function. Utilizing further bioinformatics analyses, we also identified novel central (‘hub’) proteins within these clusters, whose genes may also be implicated in aberrant self-grooming and other repetitive behaviors in general. Untangling complex molecular pathways of this important behavior using in silico approaches contributes to our understanding of related neurological disorders, and may suggest novel potential targets for their pharmacological or gene therapy.

AB - Rodent self-grooming is an important complex behavior, and its deficits are translationally relevant to a wide range of neuropsychiatric disorders. Here, we analyzed a comprehensive dataset of 227 genes whose mutations are known to evoke aberrant self-grooming in mice. Using these genes, we constructed the network of their established protein-protein interactions (PPI), yielding several distinct molecular clusters related to postsynaptic density, the Wnt signaling, transcription factors, neuronal cell cycle, NOS neurotransmission, microtubule regulation, neuronal differentiation/trafficking, neurodevelopment and mitochondrial function. Utilizing further bioinformatics analyses, we also identified novel central (‘hub’) proteins within these clusters, whose genes may also be implicated in aberrant self-grooming and other repetitive behaviors in general. Untangling complex molecular pathways of this important behavior using in silico approaches contributes to our understanding of related neurological disorders, and may suggest novel potential targets for their pharmacological or gene therapy.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85168747978

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001069491000001

U2 - 10.1016/j.pnpbp.2023.110840

DO - 10.1016/j.pnpbp.2023.110840

M3 - Article

VL - 127

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

M1 - 110840

ER -

ID: 44705130