This review considers methods for the synthesis of pyrimido[1,2-a]indoles and their ring-fused derivatives, covering publications from the last 10 years. Depending on the synthons used for assembling the target structure, three main approaches to the synthesis of pyrimido-[1,2-a]indoles can be distinguished: annulation of a pyrimidine ring to 2-aminoindoles, modification of other indole derivatives, and miscellaneous methods. [Figure not available: see fulltext.]