Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents

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Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents. / Duru, Kingsley; Kovaleva, Elena; Hildreth, Cara M. et al.
In: Journal of Functional Foods, Vol. 114, 106060, 2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{be596d79f3204fb88e3f9c9d3e5bafd3,

title = "Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents",

abstract = "Isoflavones have been identified as potential anti-diabetic agents, but adverse side effects especially at high dosage has continued to plague their clinical uptake. We explore the benefits of individual and co-treatment of diabetic rodents with isoflavone-rich kudzu extract and chaga extract based on effect on glycemic control, regeneration of pancreatic β-cells (immunofluorescence staining assessment of pancreatic insulin and pancreatic and duodenal homeobox 1 (PDX-1) expression), cardiac function (including measurements of left ventricular hemodynamics, and arterial stiffness) and kidney function. Treatment of diabetic rodents with either isoflavone or chaga extract improved glycemic control, enhanced the co-expression of insulin and PDX-1, prevented cardiac hypertrophy, and ameliorated hypercellularity of the glomerulus, expansion of the mesangial matrix and deposition of collagen in kidney tissues. The use of both compounds combined did not provide additional benefits beyond that of each used singly. Further research focusing on exploring the optimal dosage of these combined therapies in experimental diabetes models is highly recommended. {\textcopyright} 2024 The Author(s)",

author = "Kingsley Duru and Elena Kovaleva and Hildreth, {Cara M.} and Avolio, {Alberto P.} and Phillips, {Jacqueline K.} and Mark Butlin",

note = "K.C.D. was supported by the International Cotutelle Macquarie University Research Excellence Scholarship (Cotutelle iMQRES), Macquarie University, Australia. Study was funded by the Cotutelle iMQRES.",

year = "2024",

doi = "10.1016/j.jff.2024.106060",

language = "English",

volume = "114",

journal = "Journal of Functional Foods",

issn = "1756-4646",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents

AU - Duru, Kingsley

AU - Kovaleva, Elena

AU - Hildreth, Cara M.

AU - Avolio, Alberto P.

AU - Phillips, Jacqueline K.

AU - Butlin, Mark

N1 - K.C.D. was supported by the International Cotutelle Macquarie University Research Excellence Scholarship (Cotutelle iMQRES), Macquarie University, Australia. Study was funded by the Cotutelle iMQRES.

PY - 2024

Y1 - 2024

N2 - Isoflavones have been identified as potential anti-diabetic agents, but adverse side effects especially at high dosage has continued to plague their clinical uptake. We explore the benefits of individual and co-treatment of diabetic rodents with isoflavone-rich kudzu extract and chaga extract based on effect on glycemic control, regeneration of pancreatic β-cells (immunofluorescence staining assessment of pancreatic insulin and pancreatic and duodenal homeobox 1 (PDX-1) expression), cardiac function (including measurements of left ventricular hemodynamics, and arterial stiffness) and kidney function. Treatment of diabetic rodents with either isoflavone or chaga extract improved glycemic control, enhanced the co-expression of insulin and PDX-1, prevented cardiac hypertrophy, and ameliorated hypercellularity of the glomerulus, expansion of the mesangial matrix and deposition of collagen in kidney tissues. The use of both compounds combined did not provide additional benefits beyond that of each used singly. Further research focusing on exploring the optimal dosage of these combined therapies in experimental diabetes models is highly recommended. © 2024 The Author(s)

AB - Isoflavones have been identified as potential anti-diabetic agents, but adverse side effects especially at high dosage has continued to plague their clinical uptake. We explore the benefits of individual and co-treatment of diabetic rodents with isoflavone-rich kudzu extract and chaga extract based on effect on glycemic control, regeneration of pancreatic β-cells (immunofluorescence staining assessment of pancreatic insulin and pancreatic and duodenal homeobox 1 (PDX-1) expression), cardiac function (including measurements of left ventricular hemodynamics, and arterial stiffness) and kidney function. Treatment of diabetic rodents with either isoflavone or chaga extract improved glycemic control, enhanced the co-expression of insulin and PDX-1, prevented cardiac hypertrophy, and ameliorated hypercellularity of the glomerulus, expansion of the mesangial matrix and deposition of collagen in kidney tissues. The use of both compounds combined did not provide additional benefits beyond that of each used singly. Further research focusing on exploring the optimal dosage of these combined therapies in experimental diabetes models is highly recommended. © 2024 The Author(s)

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85187283648

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001185288100001

U2 - 10.1016/j.jff.2024.106060

DO - 10.1016/j.jff.2024.106060

M3 - Article

VL - 114

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

M1 - 106060

ER -

ID: 54322070