Submicron polymer particles loaded with piperine: Preparation from fucoidan and evaluation of morphology, release profile, and antioxidant activity

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Submicron polymer particles loaded with piperine: Preparation from fucoidan and evaluation of morphology, release profile, and antioxidant activity. / Mensah, Emmanuel ; Bulya, Emmanuella ; Minin, Artem s. et al.
In: Food Hydrocolloids, Vol. 145, 109147, 01.12.2023.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{8bf76d59adc345ecbada6bca6dfb3baf,

title = "Submicron polymer particles loaded with piperine: Preparation from fucoidan and evaluation of morphology, release profile, and antioxidant activity",

abstract = "A combination of two methods, polyelectrolyte self-assembly of fucoidan–chitosan and isocyanide-based multicomponent reactions, was used to obtain submicron polymer particles suitable for lyophilization. Piperine, an alkaloid and the major bioactive compound found in black pepper, is endowed with numerous biological activities; however, its application is hindered by low solubility and poor delivery. To overcome this problem, piperine was loaded into the submicron polymer particles obtained. These particles were subjected to lyophilization to assess their ability to redisperse in aqueous solution after drying and their stability. The characterization of the nanoparticles by dynamic light scattering revealed particle sizes of 219.67 ± 0.61 and 355.63 ± 14.49 nm for fucoidan–chitosan nanoparticles and piperine-loaded nanoparticles, respectively. Also, an irregular spherical piperine-loaded nanoparticle was found using atomic force microscopy. An encapsulation efficiency of 92.78% ± 0.02% was measured with UV/visible spectroscopy. In vitro, the release profile of piperine from the nanoparticles showed a significant release and faster dissolution rate than free piperine. For the release mechanism of piperine from the nanoparticle, the Korsmeyer–Peppas model was the best fit with a correlation coefficient (R2) close to 1. The antioxidant activity of the piperine-loaded nanoparticles was significantly higher than that of the unformulated piperine. The piperine-loaded nanoparticles also exhibited positive stability against stress from lyophilization. Therefore, fucoidan–chitosan nanoparticles to improve the bioavailability of piperine, as well as enhance antioxidant activity, and could be used as a nutraceutical.",

author = "Emmanuel Mensah and Emmanuella Bulya and Minin, {Artem s.} and Maxim Mironov",

note = "Authors thank Russian Science Foundation for financial support Grant 20-66-47017. The equipment of the Ural Center for Shared Use « Modern nanotechnology » Ural Federal University (Reg.№ 2968) which is supported by the Ministry of Science and Higher Education RF (Project № 075-15-2021-677) was used for AFM investigation.",

year = "2023",

month = dec,

day = "1",

doi = "10.1016/j.foodhyd.2023.109147",

language = "English",

volume = "145",

journal = "Food Hydrocolloids",

issn = "0268-005X",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Submicron polymer particles loaded with piperine: Preparation from fucoidan and evaluation of morphology, release profile, and antioxidant activity

AU - Mensah, Emmanuel

AU - Bulya, Emmanuella

AU - Minin, Artem s.

AU - Mironov, Maxim

N1 - Authors thank Russian Science Foundation for financial support Grant 20-66-47017. The equipment of the Ural Center for Shared Use « Modern nanotechnology » Ural Federal University (Reg.№ 2968) which is supported by the Ministry of Science and Higher Education RF (Project № 075-15-2021-677) was used for AFM investigation.

PY - 2023/12/1

Y1 - 2023/12/1

N2 - A combination of two methods, polyelectrolyte self-assembly of fucoidan–chitosan and isocyanide-based multicomponent reactions, was used to obtain submicron polymer particles suitable for lyophilization. Piperine, an alkaloid and the major bioactive compound found in black pepper, is endowed with numerous biological activities; however, its application is hindered by low solubility and poor delivery. To overcome this problem, piperine was loaded into the submicron polymer particles obtained. These particles were subjected to lyophilization to assess their ability to redisperse in aqueous solution after drying and their stability. The characterization of the nanoparticles by dynamic light scattering revealed particle sizes of 219.67 ± 0.61 and 355.63 ± 14.49 nm for fucoidan–chitosan nanoparticles and piperine-loaded nanoparticles, respectively. Also, an irregular spherical piperine-loaded nanoparticle was found using atomic force microscopy. An encapsulation efficiency of 92.78% ± 0.02% was measured with UV/visible spectroscopy. In vitro, the release profile of piperine from the nanoparticles showed a significant release and faster dissolution rate than free piperine. For the release mechanism of piperine from the nanoparticle, the Korsmeyer–Peppas model was the best fit with a correlation coefficient (R2) close to 1. The antioxidant activity of the piperine-loaded nanoparticles was significantly higher than that of the unformulated piperine. The piperine-loaded nanoparticles also exhibited positive stability against stress from lyophilization. Therefore, fucoidan–chitosan nanoparticles to improve the bioavailability of piperine, as well as enhance antioxidant activity, and could be used as a nutraceutical.

AB - A combination of two methods, polyelectrolyte self-assembly of fucoidan–chitosan and isocyanide-based multicomponent reactions, was used to obtain submicron polymer particles suitable for lyophilization. Piperine, an alkaloid and the major bioactive compound found in black pepper, is endowed with numerous biological activities; however, its application is hindered by low solubility and poor delivery. To overcome this problem, piperine was loaded into the submicron polymer particles obtained. These particles were subjected to lyophilization to assess their ability to redisperse in aqueous solution after drying and their stability. The characterization of the nanoparticles by dynamic light scattering revealed particle sizes of 219.67 ± 0.61 and 355.63 ± 14.49 nm for fucoidan–chitosan nanoparticles and piperine-loaded nanoparticles, respectively. Also, an irregular spherical piperine-loaded nanoparticle was found using atomic force microscopy. An encapsulation efficiency of 92.78% ± 0.02% was measured with UV/visible spectroscopy. In vitro, the release profile of piperine from the nanoparticles showed a significant release and faster dissolution rate than free piperine. For the release mechanism of piperine from the nanoparticle, the Korsmeyer–Peppas model was the best fit with a correlation coefficient (R2) close to 1. The antioxidant activity of the piperine-loaded nanoparticles was significantly higher than that of the unformulated piperine. The piperine-loaded nanoparticles also exhibited positive stability against stress from lyophilization. Therefore, fucoidan–chitosan nanoparticles to improve the bioavailability of piperine, as well as enhance antioxidant activity, and could be used as a nutraceutical.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85169442365

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001061641000001

U2 - 10.1016/j.foodhyd.2023.109147

DO - 10.1016/j.foodhyd.2023.109147

M3 - Article

VL - 145

JO - Food Hydrocolloids

JF - Food Hydrocolloids

SN - 0268-005X

M1 - 109147

ER -

ID: 44703814