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Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids. / Tseilikman, Vadim E.; Fedotova, Julia O.; Tseilikman, Olga B. et al.
In: International Journal of Molecular Sciences, Vol. 24, No. 11, 9333, 2023.

Research output: Contribution to journal › Article › peer-review

Harvard

Tseilikman, VE, Fedotova, JO, Tseilikman, OB, Novak, J, Karpenko, MN, Maistrenko, VA, Lazuko, SS, Belyeva, LE, Kamel, M, Buhler , AV & Kovaleva, EG 2023, 'Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids', International Journal of Molecular Sciences, vol. 24, no. 11, 9333. https://doi.org/10.3390/ijms24119333

APA

Tseilikman, V. E., Fedotova, J. O., Tseilikman, O. B., Novak, J., Karpenko, M. N., Maistrenko, V. A., Lazuko, S. S., Belyeva, L. E., Kamel, M., Buhler , A. V., & Kovaleva, E. G. (2023). Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids. International Journal of Molecular Sciences, 24(11), [9333]. https://doi.org/10.3390/ijms24119333

Vancouver

Tseilikman VE, Fedotova JO, Tseilikman OB, Novak J, Karpenko MN, Maistrenko VA et al. Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids. International Journal of Molecular Sciences. 2023;24(11):9333. doi: 10.3390/ijms24119333

Author

Tseilikman, Vadim E. ; Fedotova, Julia O. ; Tseilikman, Olga B. et al. / Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids. In: International Journal of Molecular Sciences. 2023 ; Vol. 24, No. 11.

BibTeX

@article{1706e140d7bc461186f04e5908d2ee65,
title = "Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids",
abstract = "Glucocorticoids are metabolized by the CYP3A isoform of cytochrome P450 and by 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Experimental data suggest that post-traumatic stress disorder (PTSD) is associated with an increase in hepatic 11β-HSD-1 activity and a concomitant decrease in hepatic CYP3A activity. Trans-resveratrol, a natural polyphenol, has been extensively studied for its antipsychiatric properties. Recently, protective effects of trans-resveratrol were found in relation to PTSD. Treatment of PTSD rats with trans-resveratrol allowed the rats to be divided into two phenotypes. The first phenotype is treatment-sensitive rats (TSR), and the second phenotype is treatment-resistant rats (TRRs). In TSR rats, trans-resveratrol ameliorated anxiety-like behavior and reversed plasma corticosterone concentration abnormalities. In contrast, in TRR rats, trans-resveratrol aggravated anxiety-like behavior and decreased plasma corticosterone concentration. In TSR rats, hepatic 11β-HSD-1 activity was suppressed, with a concomitant increase in CYP3A activity. In TRR rats, the activities of both enzymes were suppressed. Thus, the resistance of PTSD rats to trans-resveratrol treatment is associated with abnormalities in hepatic metabolism of glucocorticoids. The free energy of binding of resveratrol, cortisol, and corticosterone to the human CYP3A protein was determined using the molecular mechanics Poisson–Boltzmann surface area approach, indicating that resveratrol could affect CYP3A activity. {\textcopyright} 2023 by the authors.",
author = "Tseilikman, {Vadim E.} and Fedotova, {Julia O.} and Tseilikman, {Olga B.} and Jurica Novak and Karpenko, {Marina N.} and Maistrenko, {Victoria A.} and Lazuko, {Svetlana S.} and Belyeva, {Lyudmila E.} and Mustapha Kamel and Buhler, {Alexey V.} and Kovaleva, {Elena G.}",
note = "This research was funded by Russian Scientific Foundation, Regional grant (Chelyabinsk region) number 23-15-20040.",
year = "2023",
doi = "10.3390/ijms24119333",
language = "English",
volume = "24",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",

}

RIS

TY - JOUR

T1 - Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids

AU - Tseilikman, Vadim E.

AU - Fedotova, Julia O.

AU - Tseilikman, Olga B.

AU - Novak, Jurica

AU - Karpenko, Marina N.

AU - Maistrenko, Victoria A.

AU - Lazuko, Svetlana S.

AU - Belyeva, Lyudmila E.

AU - Kamel, Mustapha

AU - Buhler , Alexey V.

AU - Kovaleva, Elena G.

N1 - This research was funded by Russian Scientific Foundation, Regional grant (Chelyabinsk region) number 23-15-20040.

PY - 2023

Y1 - 2023

N2 - Glucocorticoids are metabolized by the CYP3A isoform of cytochrome P450 and by 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Experimental data suggest that post-traumatic stress disorder (PTSD) is associated with an increase in hepatic 11β-HSD-1 activity and a concomitant decrease in hepatic CYP3A activity. Trans-resveratrol, a natural polyphenol, has been extensively studied for its antipsychiatric properties. Recently, protective effects of trans-resveratrol were found in relation to PTSD. Treatment of PTSD rats with trans-resveratrol allowed the rats to be divided into two phenotypes. The first phenotype is treatment-sensitive rats (TSR), and the second phenotype is treatment-resistant rats (TRRs). In TSR rats, trans-resveratrol ameliorated anxiety-like behavior and reversed plasma corticosterone concentration abnormalities. In contrast, in TRR rats, trans-resveratrol aggravated anxiety-like behavior and decreased plasma corticosterone concentration. In TSR rats, hepatic 11β-HSD-1 activity was suppressed, with a concomitant increase in CYP3A activity. In TRR rats, the activities of both enzymes were suppressed. Thus, the resistance of PTSD rats to trans-resveratrol treatment is associated with abnormalities in hepatic metabolism of glucocorticoids. The free energy of binding of resveratrol, cortisol, and corticosterone to the human CYP3A protein was determined using the molecular mechanics Poisson–Boltzmann surface area approach, indicating that resveratrol could affect CYP3A activity. © 2023 by the authors.

AB - Glucocorticoids are metabolized by the CYP3A isoform of cytochrome P450 and by 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Experimental data suggest that post-traumatic stress disorder (PTSD) is associated with an increase in hepatic 11β-HSD-1 activity and a concomitant decrease in hepatic CYP3A activity. Trans-resveratrol, a natural polyphenol, has been extensively studied for its antipsychiatric properties. Recently, protective effects of trans-resveratrol were found in relation to PTSD. Treatment of PTSD rats with trans-resveratrol allowed the rats to be divided into two phenotypes. The first phenotype is treatment-sensitive rats (TSR), and the second phenotype is treatment-resistant rats (TRRs). In TSR rats, trans-resveratrol ameliorated anxiety-like behavior and reversed plasma corticosterone concentration abnormalities. In contrast, in TRR rats, trans-resveratrol aggravated anxiety-like behavior and decreased plasma corticosterone concentration. In TSR rats, hepatic 11β-HSD-1 activity was suppressed, with a concomitant increase in CYP3A activity. In TRR rats, the activities of both enzymes were suppressed. Thus, the resistance of PTSD rats to trans-resveratrol treatment is associated with abnormalities in hepatic metabolism of glucocorticoids. The free energy of binding of resveratrol, cortisol, and corticosterone to the human CYP3A protein was determined using the molecular mechanics Poisson–Boltzmann surface area approach, indicating that resveratrol could affect CYP3A activity. © 2023 by the authors.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85161670578

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001005032200001

U2 - 10.3390/ijms24119333

DO - 10.3390/ijms24119333

M3 - Article

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 11

M1 - 9333

ER -

ID: 40599406