Quinazolines annelated at the N(3)–C(4) bond: Synthesis and biological activity

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Quinazolines annelated at the N(3)–C(4) bond: Synthesis and biological activity. / Nosova, Emiliya ; Lipunova, Galina ; Permyakova, Yulia et al.
In: European Journal of Medicinal Chemistry, Vol. 271, 116411, 01.05.2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{c019809f04a9499e82a62ff0be8e36a5,

title = "Quinazolines annelated at the N(3)–C(4) bond: Synthesis and biological activity",

abstract = "This review covers article and patent data obtained mostly within the period 2013–2023 on the synthesis and biological activity of quinazolines [c]-annelated by five- and six-membered heterocycles. Pyrazolo-, benzimidazo-, triazolo- and pyrimido- [c]quinazoline systems have shown multiple potential activities against numerous targets. We highlight that most research efforts are directed to design of anticancer and antibacterial agents of azolo[c]quinazoline nature. This review emphases both on the medicinal chemistry aspects of pyrrolo[c]-, azolo[c]- and azino[c]quinazolines and comprehensive synthetic strategies of quinazolines annelated at N(3)–C(4) bond in the perspective of drug development and discovery.",

author = "Emiliya Nosova and Galina Lipunova and Yulia Permyakova and Valery Charushin",

note = "Funding from Ministry of Science and Higher Education of the Russian Federation, project FEUZ-2023-0021\u00BB.",

year = "2024",

month = may,

day = "1",

doi = "10.1016/j.ejmech.2024.116411",

language = "English",

volume = "271",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Quinazolines annelated at the N(3)–C(4) bond: Synthesis and biological activity

AU - Nosova, Emiliya

AU - Lipunova, Galina

AU - Permyakova, Yulia

AU - Charushin, Valery

N1 - Funding from Ministry of Science and Higher Education of the Russian Federation, project FEUZ-2023-0021\u00BB.

PY - 2024/5/1

Y1 - 2024/5/1

N2 - This review covers article and patent data obtained mostly within the period 2013–2023 on the synthesis and biological activity of quinazolines [c]-annelated by five- and six-membered heterocycles. Pyrazolo-, benzimidazo-, triazolo- and pyrimido- [c]quinazoline systems have shown multiple potential activities against numerous targets. We highlight that most research efforts are directed to design of anticancer and antibacterial agents of azolo[c]quinazoline nature. This review emphases both on the medicinal chemistry aspects of pyrrolo[c]-, azolo[c]- and azino[c]quinazolines and comprehensive synthetic strategies of quinazolines annelated at N(3)–C(4) bond in the perspective of drug development and discovery.

AB - This review covers article and patent data obtained mostly within the period 2013–2023 on the synthesis and biological activity of quinazolines [c]-annelated by five- and six-membered heterocycles. Pyrazolo-, benzimidazo-, triazolo- and pyrimido- [c]quinazoline systems have shown multiple potential activities against numerous targets. We highlight that most research efforts are directed to design of anticancer and antibacterial agents of azolo[c]quinazoline nature. This review emphases both on the medicinal chemistry aspects of pyrrolo[c]-, azolo[c]- and azino[c]quinazolines and comprehensive synthetic strategies of quinazolines annelated at N(3)–C(4) bond in the perspective of drug development and discovery.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85191153669

U2 - 10.1016/j.ejmech.2024.116411

DO - 10.1016/j.ejmech.2024.116411

M3 - Article

VL - 271

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

M1 - 116411

ER -

ID: 56642868