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Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies. / Okechukwu, Queency; Adepoju, Feyisayo; Kanwugu, Osman et al.
In: Pharmaceuticals, Vol. 17, No. 3, 328, 2024.

Research output: Contribution to journal › Review article › peer-review

Harvard

Okechukwu, Q, Adepoju, F, Kanwugu, O, Adadi, P, Serrano-Aroca, Á, Uversky, V & Okpala, C 2024, 'Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies', Pharmaceuticals, vol. 17, no. 3, 328. https://doi.org/10.3390/ph17030328

APA

Okechukwu, Q., Adepoju, F., Kanwugu, O., Adadi, P., Serrano-Aroca, Á., Uversky, V., & Okpala, C. (2024). Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies. Pharmaceuticals, 17(3), [328]. https://doi.org/10.3390/ph17030328

Vancouver

Okechukwu Q, Adepoju F, Kanwugu O, Adadi P, Serrano-Aroca Á, Uversky V et al. Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies. Pharmaceuticals. 2024;17(3):328. doi: 10.3390/ph17030328

Author

Okechukwu, Queency ; Adepoju, Feyisayo ; Kanwugu, Osman et al. / Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies. In: Pharmaceuticals. 2024 ; Vol. 17, No. 3.

BibTeX

@article{6a4a03932d15402f972b4df2f46e27a2,
title = "Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies",
abstract = "Worldwide urbanization and subsequent migration have accelerated the emergence and spread of diverse novel human diseases. Among them, diseases caused by viruses could result in epidemics, typified by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which hit the globe towards the end of December 2019. The global battle against SARS-CoV-2 has reignited interest in finding alternative treatments for viral infections. The marine world offers a large repository of diverse and unique bioactive compounds. Over the years, many antiviral compounds from marine organisms have been isolated and tested in vitro and in vivo. However, given the increasing need for alternative treatment, in silico analysis appears to provide a time- and cost-effective approach to identifying the potential antiviral compounds from the vast pool of natural metabolites isolated from marine organisms. In this perspective review, we discuss marine-derived bioactive metabolites as potential therapeutics for all known disease-causing viruses including the SARS-CoV-2. We demonstrate the efficacy of marine-derived bioactive metabolites in the context of various antiviral activities and their in silico, in vitro, and in vivo capacities.",
author = "Queency Okechukwu and Feyisayo Adepoju and Osman Kanwugu and Parise Adadi and {\'A}ngel Serrano-Aroca and Vladimir Uversky and Charles Okpala",
note = "Текст о финансировании Authors Q.N.O. and F.O.A., gratefully acknowledge the research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program).",
year = "2024",
doi = "10.3390/ph17030328",
language = "English",
volume = "17",
journal = "Pharmaceuticals",
issn = "1424-8247",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

RIS

TY - JOUR

T1 - Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies

AU - Okechukwu, Queency

AU - Adepoju, Feyisayo

AU - Kanwugu, Osman

AU - Adadi, Parise

AU - Serrano-Aroca, Ángel

AU - Uversky, Vladimir

AU - Okpala, Charles

N1 - Текст о финансировании Authors Q.N.O. and F.O.A., gratefully acknowledge the research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program).

PY - 2024

Y1 - 2024

N2 - Worldwide urbanization and subsequent migration have accelerated the emergence and spread of diverse novel human diseases. Among them, diseases caused by viruses could result in epidemics, typified by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which hit the globe towards the end of December 2019. The global battle against SARS-CoV-2 has reignited interest in finding alternative treatments for viral infections. The marine world offers a large repository of diverse and unique bioactive compounds. Over the years, many antiviral compounds from marine organisms have been isolated and tested in vitro and in vivo. However, given the increasing need for alternative treatment, in silico analysis appears to provide a time- and cost-effective approach to identifying the potential antiviral compounds from the vast pool of natural metabolites isolated from marine organisms. In this perspective review, we discuss marine-derived bioactive metabolites as potential therapeutics for all known disease-causing viruses including the SARS-CoV-2. We demonstrate the efficacy of marine-derived bioactive metabolites in the context of various antiviral activities and their in silico, in vitro, and in vivo capacities.

AB - Worldwide urbanization and subsequent migration have accelerated the emergence and spread of diverse novel human diseases. Among them, diseases caused by viruses could result in epidemics, typified by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which hit the globe towards the end of December 2019. The global battle against SARS-CoV-2 has reignited interest in finding alternative treatments for viral infections. The marine world offers a large repository of diverse and unique bioactive compounds. Over the years, many antiviral compounds from marine organisms have been isolated and tested in vitro and in vivo. However, given the increasing need for alternative treatment, in silico analysis appears to provide a time- and cost-effective approach to identifying the potential antiviral compounds from the vast pool of natural metabolites isolated from marine organisms. In this perspective review, we discuss marine-derived bioactive metabolites as potential therapeutics for all known disease-causing viruses including the SARS-CoV-2. We demonstrate the efficacy of marine-derived bioactive metabolites in the context of various antiviral activities and their in silico, in vitro, and in vivo capacities.

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001192465200001

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85189021369

U2 - 10.3390/ph17030328

DO - 10.3390/ph17030328

M3 - Review article

VL - 17

JO - Pharmaceuticals

JF - Pharmaceuticals

SN - 1424-8247

IS - 3

M1 - 328

ER -

ID: 55352140