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Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation. / Tseilikman, Vadim; Shatilov, Vladislav A.; Zhukov, Maxim S. et al.
In: International Journal of Molecular Sciences, Vol. 24, No. 18, 14343, 2023.

Research output: Contribution to journalArticlepeer-review

Harvard

Tseilikman, V, Shatilov, VA, Zhukov, MS, Buksha, IA, Epitashvily, AE, Lipatov, IA, Aristov, MR, Koshelev, AG, Karpenko, M, Traktirov, DS, Maistrenko, VA, Kamel, M, Buhler, A, Kovaleva, E, Kalinina, TS, Pashkov, AA, Kon’kov, VV, Novak, J & Tseilikman, O 2023, 'Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation', International Journal of Molecular Sciences, vol. 24, no. 18, 14343. https://doi.org/10.3390/ijms241814343

APA

Tseilikman, V., Shatilov, V. A., Zhukov, M. S., Buksha, I. A., Epitashvily, A. E., Lipatov, I. A., Aristov, M. R., Koshelev, A. G., Karpenko, M., Traktirov, D. S., Maistrenko, V. A., Kamel, M., Buhler, A., Kovaleva, E., Kalinina, T. S., Pashkov, A. A., Kon’kov, V. V., Novak, J., & Tseilikman, O. (2023). Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation. International Journal of Molecular Sciences, 24(18), [14343]. https://doi.org/10.3390/ijms241814343

Vancouver

Tseilikman V, Shatilov VA, Zhukov MS, Buksha IA, Epitashvily AE, Lipatov IA et al. Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation. International Journal of Molecular Sciences. 2023;24(18):14343. doi: 10.3390/ijms241814343

Author

Tseilikman, Vadim ; Shatilov, Vladislav A. ; Zhukov, Maxim S. et al. / Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation. In: International Journal of Molecular Sciences. 2023 ; Vol. 24, No. 18.

BibTeX

@article{731b399e4c044e5ba34eaf3d9972f413,
title = "Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation",
abstract = "Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD. {\textcopyright} 2023 by the authors.",
author = "Vadim Tseilikman and Shatilov, {Vladislav A.} and Zhukov, {Maxim S.} and Buksha, {Irina A.} and Epitashvily, {Alexandr E.} and Lipatov, {Ilya A.} and Aristov, {Maxim R.} and Koshelev, {Alexandr G.} and Marina Karpenko and Traktirov, {Dmitrii S.} and Maistrenko, {Viktoriya A.} and Mustapha Kamel and Alexey Buhler and Elena Kovaleva and Kalinina, {Tatyana S.} and Pashkov, {Anton A.} and Kon{\textquoteright}kov, {Vadim V.} and Jurica Novak and Olga Tseilikman",
note = "This work was supported by the Russian Scientific Foundation, Regional grant, Chelyabinsk Region (#23-15-20040).",
year = "2023",
doi = "10.3390/ijms241814343",
language = "English",
volume = "24",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "18",

}

RIS

TY - JOUR

T1 - Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation

AU - Tseilikman, Vadim

AU - Shatilov, Vladislav A.

AU - Zhukov, Maxim S.

AU - Buksha, Irina A.

AU - Epitashvily, Alexandr E.

AU - Lipatov, Ilya A.

AU - Aristov, Maxim R.

AU - Koshelev, Alexandr G.

AU - Karpenko, Marina

AU - Traktirov, Dmitrii S.

AU - Maistrenko, Viktoriya A.

AU - Kamel, Mustapha

AU - Buhler, Alexey

AU - Kovaleva, Elena

AU - Kalinina, Tatyana S.

AU - Pashkov, Anton A.

AU - Kon’kov, Vadim V.

AU - Novak, Jurica

AU - Tseilikman, Olga

N1 - This work was supported by the Russian Scientific Foundation, Regional grant, Chelyabinsk Region (#23-15-20040).

PY - 2023

Y1 - 2023

N2 - Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD. © 2023 by the authors.

AB - Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD. © 2023 by the authors.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85172768878

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001074050800001

U2 - 10.3390/ijms241814343

DO - 10.3390/ijms241814343

M3 - Article

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 18

M1 - 14343

ER -

ID: 46011041