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Genotoxic Effects of New Azoloazine Derivatives with Antitumor Activity in MCF-7 Tumor Cell Culture. / Al-Humain, A. H.; Speranskiy, D.; Rybalkina, O. et al.
In: Pharmaceutical Chemistry Journal, Vol. 57, No. 6, 2023, p. 822-827.

Research output: Contribution to journal › Article › peer-review

Harvard

Al-Humain, AH, Speranskiy, D, Rybalkina, O, Sadchikova, E, Buldakov, M, Frolova, A, Cherdyntseva, N & Udut, V 2023, 'Genotoxic Effects of New Azoloazine Derivatives with Antitumor Activity in MCF-7 Tumor Cell Culture', Pharmaceutical Chemistry Journal, vol. 57, no. 6, pp. 822-827. https://doi.org/10.1007/s11094-023-02955-5

APA

Al-Humain, A. H., Speranskiy, D., Rybalkina, O., Sadchikova, E., Buldakov, M., Frolova, A., Cherdyntseva, N., & Udut, V. (2023). Genotoxic Effects of New Azoloazine Derivatives with Antitumor Activity in MCF-7 Tumor Cell Culture. Pharmaceutical Chemistry Journal, 57(6), 822-827. https://doi.org/10.1007/s11094-023-02955-5

Vancouver

Al-Humain AH, Speranskiy D, Rybalkina O, Sadchikova E, Buldakov M, Frolova A et al. Genotoxic Effects of New Azoloazine Derivatives with Antitumor Activity in MCF-7 Tumor Cell Culture. Pharmaceutical Chemistry Journal. 2023;57(6):822-827. doi: 10.1007/s11094-023-02955-5

Author

Al-Humain, A. H. ; Speranskiy, D. ; Rybalkina, O. et al. / Genotoxic Effects of New Azoloazine Derivatives with Antitumor Activity in MCF-7 Tumor Cell Culture. In: Pharmaceutical Chemistry Journal. 2023 ; Vol. 57, No. 6. pp. 822-827.

BibTeX

@article{0c6fcc378c9942839fd13949beeb5b56,
title = "Genotoxic Effects of New Azoloazine Derivatives with Antitumor Activity in MCF-7 Tumor Cell Culture",
abstract = "The genotoxic properties of three new azoloazine derivatives (azoloazines 1 – 3) exhibiting cytotoxic activity were studied in an in vitro experiment using MCF-7 human breast cancer cell culture. Acomparison of the effects of azoloazines 1 – 3 at doses of 1/2, 1/10, and 1/50 of IC50 with those of epirubicin at the same doses on the main indicators of damage to the genetic apparatus of the cells revealed that the studied compounds had the greatest toxic effect on DNAat a dose 1/10 of IC50. The genotoxicity of azoloazines 1 – 3 at a dose 1/10 of IC50 was shown to exceed that of epirubicin. {\textcopyright} 2023, Springer Science+Business Media, LLC, part of Springer Nature.",
author = "Al-Humain, {A. H.} and D. Speranskiy and O. Rybalkina and E. Sadchikova and M. Buldakov and A. Frolova and N. Cherdyntseva and V. Udut",
year = "2023",
doi = "10.1007/s11094-023-02955-5",
language = "English",
volume = "57",
pages = "822--827",
journal = "Pharmaceutical Chemistry Journal",
issn = "0091-150X",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Genotoxic Effects of New Azoloazine Derivatives with Antitumor Activity in MCF-7 Tumor Cell Culture

AU - Al-Humain, A. H.

AU - Speranskiy, D.

AU - Rybalkina, O.

AU - Sadchikova, E.

AU - Buldakov, M.

AU - Frolova, A.

AU - Cherdyntseva, N.

AU - Udut, V.

PY - 2023

Y1 - 2023

N2 - The genotoxic properties of three new azoloazine derivatives (azoloazines 1 – 3) exhibiting cytotoxic activity were studied in an in vitro experiment using MCF-7 human breast cancer cell culture. Acomparison of the effects of azoloazines 1 – 3 at doses of 1/2, 1/10, and 1/50 of IC50 with those of epirubicin at the same doses on the main indicators of damage to the genetic apparatus of the cells revealed that the studied compounds had the greatest toxic effect on DNAat a dose 1/10 of IC50. The genotoxicity of azoloazines 1 – 3 at a dose 1/10 of IC50 was shown to exceed that of epirubicin. © 2023, Springer Science+Business Media, LLC, part of Springer Nature.

AB - The genotoxic properties of three new azoloazine derivatives (azoloazines 1 – 3) exhibiting cytotoxic activity were studied in an in vitro experiment using MCF-7 human breast cancer cell culture. Acomparison of the effects of azoloazines 1 – 3 at doses of 1/2, 1/10, and 1/50 of IC50 with those of epirubicin at the same doses on the main indicators of damage to the genetic apparatus of the cells revealed that the studied compounds had the greatest toxic effect on DNAat a dose 1/10 of IC50. The genotoxicity of azoloazines 1 – 3 at a dose 1/10 of IC50 was shown to exceed that of epirubicin. © 2023, Springer Science+Business Media, LLC, part of Springer Nature.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85174246514

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001084566600003

U2 - 10.1007/s11094-023-02955-5

DO - 10.1007/s11094-023-02955-5

M3 - Article

VL - 57

SP - 822

EP - 827

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

SN - 0091-150X

IS - 6

ER -

ID: 48499386