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Analog of antiviral drug Triazavirin (Riamilovir) labeled with stable isotopes 13C and 15N. Synthesis and NMR characteristics. / Shestakova, T.; Deev, S.; Eltsov, O. et al.
In: Russian Chemical Bulletin, Vol. 73, No. 2, 2024, p. 372-378.

Research output: Contribution to journal › Article › peer-review

Harvard

Shestakova, T, Deev, S, Eltsov, O, Khalymbadzha, I, Shevyrin, V, Rusinov, V, Charushin, V & Chupakhin, O 2024, 'Analog of antiviral drug Triazavirin (Riamilovir) labeled with stable isotopes 13C and 15N. Synthesis and NMR characteristics', Russian Chemical Bulletin, vol. 73, no. 2, pp. 372-378. https://doi.org/10.1007/s11172-024-4144-7

APA

Shestakova, T., Deev, S., Eltsov, O., Khalymbadzha, I., Shevyrin, V., Rusinov, V., Charushin, V., & Chupakhin, O. (2024). Analog of antiviral drug Triazavirin (Riamilovir) labeled with stable isotopes 13C and 15N. Synthesis and NMR characteristics. Russian Chemical Bulletin, 73(2), 372-378. https://doi.org/10.1007/s11172-024-4144-7

Vancouver

Shestakova T, Deev S, Eltsov O, Khalymbadzha I, Shevyrin V, Rusinov V et al. Analog of antiviral drug Triazavirin (Riamilovir) labeled with stable isotopes 13C and 15N. Synthesis and NMR characteristics. Russian Chemical Bulletin. 2024;73(2):372-378. doi: 10.1007/s11172-024-4144-7

Author

Shestakova, T. ; Deev, S. ; Eltsov, O. et al. / Analog of antiviral drug Triazavirin (Riamilovir) labeled with stable isotopes 13C and 15N. Synthesis and NMR characteristics. In: Russian Chemical Bulletin. 2024 ; Vol. 73, No. 2. pp. 372-378.

BibTeX

@article{b75e8565d20a44d3bad34783bfeccf7f,
title = "Analog of antiviral drug Triazavirin (Riamilovir) labeled with stable isotopes 13C and 15N. Synthesis and NMR characteristics",
abstract = "The synthesis of analog of Triazavirin (Riamilovir) enriched with isotopic 13C and 15N labels, viz. monohydrate of l-arginine salt of 5-methyl-6-nitro-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine was developed. To incorporate 13C and 15N stable isotopes into its structure, [5-13C]-3-amino-1,2,4-triazole (13C, 99%), ethyl [1,2,3,4-13C4]-acetoacetate (13C, 99%), and potassium 15N-nitrate (15N, 99%) were used. The presence of 13C and 15N atoms allowed us to estimate spin—spin coupling constants for the 13C-13C and 13C-15N interactions in the NMR spectra of labeled [1,2,4]triazolo[1,5-a]pyrimidine derivatives. {\textcopyright} Springer Science+Business Media LLC 2024.",
author = "T. Shestakova and S. Deev and O. Eltsov and I. Khalymbadzha and V. Shevyrin and V. Rusinov and V. Charushin and O. Chupakhin",
year = "2024",
doi = "10.1007/s11172-024-4144-7",
language = "English",
volume = "73",
pages = "372--378",
journal = "Russian Chemical Bulletin",
issn = "1066-5285",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Analog of antiviral drug Triazavirin (Riamilovir) labeled with stable isotopes 13C and 15N. Synthesis and NMR characteristics

AU - Shestakova, T.

AU - Deev, S.

AU - Eltsov, O.

AU - Khalymbadzha, I.

AU - Shevyrin, V.

AU - Rusinov, V.

AU - Charushin, V.

AU - Chupakhin, O.

PY - 2024

Y1 - 2024

N2 - The synthesis of analog of Triazavirin (Riamilovir) enriched with isotopic 13C and 15N labels, viz. monohydrate of l-arginine salt of 5-methyl-6-nitro-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine was developed. To incorporate 13C and 15N stable isotopes into its structure, [5-13C]-3-amino-1,2,4-triazole (13C, 99%), ethyl [1,2,3,4-13C4]-acetoacetate (13C, 99%), and potassium 15N-nitrate (15N, 99%) were used. The presence of 13C and 15N atoms allowed us to estimate spin—spin coupling constants for the 13C-13C and 13C-15N interactions in the NMR spectra of labeled [1,2,4]triazolo[1,5-a]pyrimidine derivatives. © Springer Science+Business Media LLC 2024.

AB - The synthesis of analog of Triazavirin (Riamilovir) enriched with isotopic 13C and 15N labels, viz. monohydrate of l-arginine salt of 5-methyl-6-nitro-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine was developed. To incorporate 13C and 15N stable isotopes into its structure, [5-13C]-3-amino-1,2,4-triazole (13C, 99%), ethyl [1,2,3,4-13C4]-acetoacetate (13C, 99%), and potassium 15N-nitrate (15N, 99%) were used. The presence of 13C and 15N atoms allowed us to estimate spin—spin coupling constants for the 13C-13C and 13C-15N interactions in the NMR spectra of labeled [1,2,4]triazolo[1,5-a]pyrimidine derivatives. © Springer Science+Business Media LLC 2024.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85187893445

U2 - 10.1007/s11172-024-4144-7

DO - 10.1007/s11172-024-4144-7

M3 - Article

VL - 73

SP - 372

EP - 378

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

SN - 1066-5285

IS - 2

ER -

ID: 54317814