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Amino Derivatives of Acridine: Synthesis and Study of Anticholinesterase and Antioxidant Activity. / Shchepochkin, A. V.; Uglova, A. F.; Utepova, I. A. et al.
In: Doklady Chemistry, Vol. 509, No. 2, 01.04.2023, p. 100-105.

Research output: Contribution to journal › Article › peer-review

Harvard

Shchepochkin, AV, Uglova, AF, Utepova, IA, Gradoblyanskaya, ES, Averkov, MA, Kovaleva, NV, Rudakova, EV, Boltneva, NP, Serebryakova, OG, Makhaeva, GF, Charushin, VN & Chupakhin, ON 2023, 'Amino Derivatives of Acridine: Synthesis and Study of Anticholinesterase and Antioxidant Activity', Doklady Chemistry, vol. 509, no. 2, pp. 100-105. https://doi.org/10.1134/S0012500823700167

APA

Shchepochkin, A. V., Uglova, A. F., Utepova, I. A., Gradoblyanskaya, E. S., Averkov, M. A., Kovaleva, N. V., Rudakova, E. V., Boltneva, N. P., Serebryakova, O. G., Makhaeva, G. F., Charushin, V. N., & Chupakhin, O. N. (2023). Amino Derivatives of Acridine: Synthesis and Study of Anticholinesterase and Antioxidant Activity. Doklady Chemistry, 509(2), 100-105. https://doi.org/10.1134/S0012500823700167

Vancouver

Shchepochkin AV, Uglova AF, Utepova IA, Gradoblyanskaya ES, Averkov MA, Kovaleva NV et al. Amino Derivatives of Acridine: Synthesis and Study of Anticholinesterase and Antioxidant Activity. Doklady Chemistry. 2023 Apr 1;509(2):100-105. doi: 10.1134/S0012500823700167

Author

Shchepochkin, A. V. ; Uglova, A. F. ; Utepova, I. A. et al. / Amino Derivatives of Acridine: Synthesis and Study of Anticholinesterase and Antioxidant Activity. In: Doklady Chemistry. 2023 ; Vol. 509, No. 2. pp. 100-105.

BibTeX

@article{60f1e24b7c054c3e91134dff6ba255fc,
title = "Amino Derivatives of Acridine: Synthesis and Study of Anticholinesterase and Antioxidant Activity",
abstract = "A simple and feasible approach to the synthesis of new amine derivatives of acridine based on the methodology of direct C–H functionalization has been developed. The inhibitory effect of the synthesized compounds toward cholinesterases and carboxylesterase as well as their antioxidant activity have been studied. A high anti-BChE activity has been shown for N-methylpiperazine derivative promising for further optimization to design on its basis new series of compounds efficient for the treatment of neurodegenerative diseases.",
author = "Shchepochkin, {A. V.} and Uglova, {A. F.} and Utepova, {I. A.} and Gradoblyanskaya, {E. S.} and Averkov, {M. A.} and Kovaleva, {N. V.} and Rudakova, {E. V.} and Boltneva, {N. P.} and Serebryakova, {O. G.} and Makhaeva, {G. F.} and Charushin, {V. N.} and Chupakhin, {O. N.}",
note = "Synthetic part of the work was supported by the Russian Foundation for Basic Research (project no. 19-29-08037 mk). The study of biological activity was supported in part by the Russian Science Foundation and the State Assignment for the Institute of Physiologically Active Compounds, RAS, no. FFSN-2021-0005.",
year = "2023",
month = apr,
day = "1",
doi = "10.1134/S0012500823700167",
language = "English",
volume = "509",
pages = "100--105",
journal = "Doklady Chemistry",
issn = "0012-5008",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "2",

}

RIS

TY - JOUR

T1 - Amino Derivatives of Acridine: Synthesis and Study of Anticholinesterase and Antioxidant Activity

AU - Shchepochkin, A. V.

AU - Uglova, A. F.

AU - Utepova, I. A.

AU - Gradoblyanskaya, E. S.

AU - Averkov, M. A.

AU - Kovaleva, N. V.

AU - Rudakova, E. V.

AU - Boltneva, N. P.

AU - Serebryakova, O. G.

AU - Makhaeva, G. F.

AU - Charushin, V. N.

AU - Chupakhin, O. N.

N1 - Synthetic part of the work was supported by the Russian Foundation for Basic Research (project no. 19-29-08037 mk). The study of biological activity was supported in part by the Russian Science Foundation and the State Assignment for the Institute of Physiologically Active Compounds, RAS, no. FFSN-2021-0005.

PY - 2023/4/1

Y1 - 2023/4/1

N2 - A simple and feasible approach to the synthesis of new amine derivatives of acridine based on the methodology of direct C–H functionalization has been developed. The inhibitory effect of the synthesized compounds toward cholinesterases and carboxylesterase as well as their antioxidant activity have been studied. A high anti-BChE activity has been shown for N-methylpiperazine derivative promising for further optimization to design on its basis new series of compounds efficient for the treatment of neurodegenerative diseases.

AB - A simple and feasible approach to the synthesis of new amine derivatives of acridine based on the methodology of direct C–H functionalization has been developed. The inhibitory effect of the synthesized compounds toward cholinesterases and carboxylesterase as well as their antioxidant activity have been studied. A high anti-BChE activity has been shown for N-methylpiperazine derivative promising for further optimization to design on its basis new series of compounds efficient for the treatment of neurodegenerative diseases.

UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85163841198

UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=001020982300002

U2 - 10.1134/S0012500823700167

DO - 10.1134/S0012500823700167

M3 - Article

VL - 509

SP - 100

EP - 105

JO - Doklady Chemistry

JF - Doklady Chemistry

SN - 0012-5008

IS - 2

ER -

ID: 41525809