FIELD: pharmaceutics. SUBSTANCE: invention relates to new 3-aryl-4-(trifluoromethyl)-4H-spiro[chromeno[3,4-c]pyrrolidine-1,3'-oxindoles] of general formula I, as well as a method for their preparation. EFFECT: new compounds have been obtained that have high cytotoxic activity in relation to the cells of human uterine neck carcinoma, HeLa line, and can be used as antitumor drugs. 2 cl, 1 dwg, 2 tbl, 26 ex.