The possibility of the synthesis of the 1,2,4-triazines with 2-(aminophenyl)-1,3,4-oxadiazole moieties at С5 position by nucleophilic ipso -substitution of cyanogroup under solvent-free conditions has been demonstrated. It has been shown that the reaction occurs regardless of the position of the amino group ( para - or meta -) in the aromatic substituent of 1,3,4-oxadiazole.