The most important criterion of the skin regeneration effectiveness is the restoration of its structure, in particular re-epithelialization, the development of granulation and connective tissue at the site of the defect, and the blood vessels formation. The purpose of this study is to perform a morphological characteristics of the skin wound process under spiroconjugated 1,2,3-triazolo[5,1-b]1,3,4-thiadiazine (STT) applying. Materials and methods. The experiment utilized 45 white rats. The study included 3rdА degree burn injury modeling with wounds exposure to an ointment containing STT. A morphological description of skin was carried out with an assessment of the following parameters: wound area, epidermis thickness, fibroblasts number, as well as mast cells and blood vessels, vessels area and diameter. Results. Under STT influence of on the wound process, by the 7th day of the experiment, an increased number of fibroblasts was noted in the granulation tissue. By the 14th day of the experiment, complete epithelialization of the defect took place, as well as scar formation with a developed fibrous component. By the 21st day, partial restoration of epidermal derivatives was observed, together with normalization of microcirculatory parameters. Conclusion. It has been shown that STT using leads to the intensification of regenerative processes. The wound defect epithelialization and the scar formation are carried out more efficiently, the newly formed tissues are similar to intact skin. These effects are mainly associated with the stimulating effect of STT on the proliferative activity of cells, including fibroblasts. The results substantiate further study of STT as a wound healing agent.