The paper presents an analysis of bone and stone industries of the Late Mesolithic and Early Neolithic of the Middle Trans-Urals. Researchers of the Neolithic usually consider that stone and bone inventories played an auxiliary role. But these features are basic for the Mesolithic where ceramic is absent. A comparison of industries of the Late Mesolithic and Early Neolithic, identification of their semblance and difference is the main indicator of the role of local Late Mesolithic traditions in the formation of Early Neolithic cultures. This research has showed a continuity of bone and stone industries of the Middle Trans-Urals from the Early Mesolithic to Early Neolithic. Main functional groups of bone artefacts, many tool types and methods of their manufacture existed during this whole time period. Transformation of bone industry during the Mesolithic - Early Neolithic manifested in emergence of new categories and types of artefacts at every stage of its development. Stone industries of the Middle and Late Mesolithic display great similarity. The continuity in the Mesolithic - Early Neolithic stone and bone industries of the Middle Trans-Urals indicates a formation of the Early Neolithic of this territory on the local substrate.