FIELD: medicine; obstetrics; gynecology; pulmonology. SUBSTANCE: invention relates to medicine, to the field of obstetrics and gynecology, pulmonology, and specifically to a method for pulmonary hypoplasia correction in fetus congenital diaphragmatic hernia in rats. The method includes lung hypoplasia simulation by oral administration of 100 mg of nitrofen on the 9th day of pregnancy and use of inhibitor of specific phosphodiesterase 5 cyclic guanosine monophosphate - PDE-5 cGMP for its correction. Use tadalafil as an inhibitor of specific PDE-5 cGMP, which is administered subcutaneously, starting from the 9th day of pregnancy at a dosage of 3.3 mg every day until the 20th day of pregnancy. EFFECT: invention provides improvement of vascularization of interalveolar septa and increase in the number of alveoli after the use of tadalafil in a nitrafen-induced VDH model in rats. 1 cl, 3 tbl.
Translated title of the contributionMethod of Forming A Model of Congenital Diaphragmatic Hernia in Rat Fetuses Using EKUM Nitrofen: patent of invention
Original languageRussian
Patent number2801603
IPCA61B 17/00,G09B 23/28,A01N 33/18,A61B 8/08
Priority date06/09/2022
Filing date06/09/2022
Publication statusPublished - 11 Aug 2023

ID: 57374030