The paper deals with resignations of regional party leaders in Russia, with the United Russia being an example. The author’s intention is to find answers to the following questions: What are the reasons for changing leaders of the United Russia regional branches? Why are many regional party leaders forced to resign? For this purpose, a database has been created to include work history of senior party managers at the subnational level. The research method used was binary logistic regression. It is shown that changing heads of the regions often results into the rotation of leaders for the United Russia subnational branches. Within two years after the Single voting day, 67% of the regional secretaries of the party appear to be dismissed and replaced. The paper gives serious attention to the cause-to-effect mechanism. It is a matter of fact that heads of the 34 regions in the Russian Federation are at the same time The United Russia regional party leaders. Based on the results of the regression analysis, the author came to the conclusion that only those governors become regional party leaders who are affiliated with the first deputy of the presidential administration. It is shown that in most cases it is not generally crucial for heads of the regions to ensure high percentages of the votes given for the United Russia party and/or incumbents in the presidential elections on the territory of the Russian Federation. To study reasons for the rotation of regional party leaders is important in terms of optimizing party work at the regional level, delivering stability, developing subnational leadership and improving effectiveness of the party structure.