The article examines the general state of the use of digital technologies in Russian healthcare institutions, the use of digital technologies in molecular genetic research, including for the detection of primary immunodeficiency in children. The authors prove that the use of digital technologies for diagnostics and timely molecular genetic verification of the diagnosis is of applied practical importance, since allows to accelerate the planning and implementation of radical therapy methods for the complete cure of patients with primary immunodeficiency. Also, carrying out molecular genetic studies using digital technologies in patients with primary immunodeficiency allows discovering new variants of nucleotide changes in DNA, accumulating data on the genetic heterogeneity of primary forms of immunodeficiency, and expanding general knowledge in the field of immunogenetics.