The article present the results of a study of the diagnostic efficacy of various SIR indicators (IL-6, IL-8, IL-10, TNFa, CRP), duration of dialysis before renal transplantation, post-allotransplantation period and HLA mismatch score (the number of mismatches from 6 antigens HLA loci A, B, DR) with respect to the development of chronic renal allograft dysfunction (CRAD). It was shown that the level of proinflamma-tory cytokine TNFa is a promising marker for the prognosis of the CRAD development.