The aging of the population, the increase in life expectancy, the growth of the subject activity of persons of older age groups on the one hand, the evolutionary normative decline in a number of cognitive functions, the expected growth of persons with cognitive problems determines the need to study cognitive functions at the stages of late ontogenesis taking into account the aging patterns of the central nervous system (CNS). A non-repetitive, selective, observational field study of changes in cognitive functions at the stages of late ontogenesis was carried out. Surveyed 148 workers aged from 27 to 74 years, all right-handed. Applied neuropsychological, statistical research methods. It was revealed that the performance of neuropsychological subtests as they age decrease unevenly, and also that young people coped better with the performance of grafomotor tests than their older colleagues. The results of this study are promising for the subsequent development of tools for the differential diagnosis of normal and pathological aging.