Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Роль ключевых эндоканнабиноидов и их рецепторов при раке молочной железы
AU - Akimov, M. G.
AU - Dudina, P. V.
AU - Vyunova, T. V.
AU - Kalueff, A. V.
AU - Gretskaya, N. M.
AU - Bezuglov, V. V.
N1 - Funding source. This study was supported by the grant of the Russian Scientific Fondation No. 23-24-00423.
PY - 2024
Y1 - 2024
N2 - Breast cancer stands as the leading cause of cancer-related deaths among women worldwide. Endocannabinoids and their exogenous analogs, e.g., tetrahydrocannabinol, exhibit antitumor effects in various animal models of cancer. However, several studies have shown that under certain conditions, treatment with cannabinoids can stimulate the proliferation of cancer cells in vitro and disrupt the immune system’s involvement in suppressing tumors. Additionally, conflicting reports exist regarding the antitumor role of endocannabinoid system in cancer. This review aims to consider the main mechanisms of action of key ligands and receptors of the endocannabinoid system within the context of breast cancer. © Eco-Vector, 2024.
AB - Breast cancer stands as the leading cause of cancer-related deaths among women worldwide. Endocannabinoids and their exogenous analogs, e.g., tetrahydrocannabinol, exhibit antitumor effects in various animal models of cancer. However, several studies have shown that under certain conditions, treatment with cannabinoids can stimulate the proliferation of cancer cells in vitro and disrupt the immune system’s involvement in suppressing tumors. Additionally, conflicting reports exist regarding the antitumor role of endocannabinoid system in cancer. This review aims to consider the main mechanisms of action of key ligands and receptors of the endocannabinoid system within the context of breast cancer. © Eco-Vector, 2024.
UR - http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85192835073
U2 - 10.17816/RCF623144
DO - 10.17816/RCF623144
M3 - Обзорная статья
VL - 22
SP - 41
EP - 51
JO - Обзоры по клинической фармакологии и лекарственной терапии
JF - Обзоры по клинической фармакологии и лекарственной терапии
SN - 1683-4100
IS - 1
ER -
ID: 57308933