The article presents the results of comparative analysis of cytokinemia (IL-6, IL-8, IL-10, TNFα) in various autoimmune diseases: autoimmune thyroiditis, valvular heart disease, psoriatic arthritis, rheumatoid arthritis, reactive arthritis, ankylosing spondylitis, chronic glomerulonephritis with end-stage renal disease, systemic lupus erythematosus. Severity of cytokine response was maximal in systemic lupus erythematosus and chronic glomerulonephritis. The greatest deviations from normal values in these autoimmune diseases were observed in TNFα and IL-8 levels.