This article presents an estimate of the number of cells with the content of heat shock protein HSP70, as well as the level of tumor necrosis factor TNF-α and IL-10 under conditions of intoxication with tetrachloromethane (CCl4). It was shown that the number of cells containing HSP70 protein granules signifi cantly increased in the thymus and spleen cells on day 3 after administration of the toxicant. The toxic eff ect of CCl4 leads to an increase in the level of TNF-α and a decrease in IL-10 in blood plasma. The results showed that the response of the body to intraperitoneal administration of CCl4 is manifested by an increase in the production of HSP70 and TNF-α, which can serve as markers of cellular damage and has prognostic and diagnostic signifi cance.